885274-21-5

Basic information

• Product Name: 2-O-TOLYL-OXAZOL-4-YL-METHYLAMINE
• Synonyms: C-(2-O-TOLYL-OXAZOL-4-YL)-METHYLAMINE;2-O-TOLYL-OXAZOL-4-YL-METHYLAMINE;(2-(o-Tolyl)oxazol-4-yl)MethanaMine;2-(2-methylphenyl)-4-Oxazolemethanamine
• CAS NO: 885274-21-5
• Molecular Formula: C11H12N2O
• Molecular Weight: 188.23
• Mol File: 885274-21-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-O-TOLYL-OXAZOL-4-YL-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-O-TOLYL-OXAZOL-4-YL-METHYLAMINE(885274-21-5)
• EPA Substance Registry System: 2-O-TOLYL-OXAZOL-4-YL-METHYLAMINE(885274-21-5)

Safety Data

• Hazardous Substances Data: 885274-21-5(Hazardous Substances Data)

Usage

General Description

2-O-TOLYL-OXAZOL-4-YL-METHYLAMINE is a chemical compound that belongs to the class of oxazoles. It is a derivative of oxazole that contains a tolyl group and a methylamine group. 2-O-TOLYL-OXAZOL-4-YL-METHYLAMINE has potential applications in pharmaceutical and chemical industries, as it can be used as a building block for the synthesis of various organic compounds. It may also have biological activities and can be used in the development of new drugs. However, the exact properties and uses of this compound may vary depending on its specific structure and purity.

Upstream product

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Relevant articles and documents

Design, synthesis, and insecticidal/acaricidal evaluation of novel pyrimidinamine derivatives containing phenyloxazole moiety

A series of novel pyrimidinamine derivatives containing phenyloxazole moiety were designed and synthesized, and their structures were characterized by 1H NMR, MS, and elemental analyses. The bioassay results displayed that some compounds exhibited remarkable insecticidal activities against Aphis fabae and Tetranychus cinnabarinus. Especially, 5-chloro-6-ethyl-2-methyl-N-((2-(p-tolyl)oxazol-4-yl)methyl)pyrimidin-4-amine (9o) showed potent activity against A. fabae, superior to that of the commercial insecticide, imidacloprid. In addition, 5-chloro-6-ethyl-2-methyl-N-((2-(4-(trifluoromethyl)phenyl)oxazol-4-yl)methyl)pyrimidin-4-amine (9r) showed potent activities against T. cinnabarinus, inferior to that of the commercial insecticide spirotetramat. The structure–activity relationship study for the target compounds was also discussed.

Design, synthesis, DFT study and antifungal activity of the derivatives of pyrazolecarboxamide containing thiazole or oxazole ring

Pyrazolecarboxamide fungicides are one of the most important classes of agricultural fungicides, which belong to succinodehydrogenase inhibitors (SDHIS). To discover new pyrazolecarboxamide analogues with broad spectrum and high activity, a class of new compounds of pyrazole carboxamide derivatives containing thiazole or oxazole ring were designed by scaffold hopping and bioisosterism, and 36 pyrazole carboxamide derivatives with antifungal activity were synthesized. Those compounds were evaluated against five phytopathogenic fungi, Gibberella zeae, Phytophythora capsici, Sclerotonia sclerotiorum, Erysiphe graminis and Puccinia sorghi. The results indicated that most of the compounds displayed good fungicidal activities, especially against E. graminis. Theoretical calculations were carried out at the B3LYP/6-31G (d, p) level and the full geometry optimization was carried out using the 6-31G (d, p) basis set, and the frontier orbital energy, atomic net charges, molecular docking were discussed, and the structure-activity relationships were also studied.