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Usage

Uses

Used in Pharmaceutical Industry:
8-Chloro-2-methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and properties make it a promising candidate for the development of new drugs with potential therapeutic applications.
Used in Chemical Industry:
In the chemical industry, 8-Chloro-2-methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester is used as a solvent for various chemical reactions. Its ability to dissolve a wide range of substances makes it a valuable component in the synthesis of other chemicals and materials.
Used in Biotechnology Industry:
8-Chloro-2-methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester may also have potential applications in the biotechnology industry. Its unique structure and properties could be utilized in the development of new biotechnological processes or products, such as in the synthesis of bioactive compounds or as a component in drug delivery systems.

Upstream product

• 39620-04-7 2-amino-3-chloropyridine 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Relevant academic research and scientific papers

Design, synthesis and biological activity of N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides as new antitubercular agents

A series of N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides (IPAs), based on the structure of WZY02 discovered in our lab, were designed and synthesized as new anti-TB agents. Results reveal that many of them exhibit excellent in vitro inhibitory activity with low nanomolar MIC values against both drug-sensitive MTB strain H37Rv and drug-resistant clinical isolates. Compounds 15b and 15d display good safety and pharmacokinetic profiles, suggesting their promising potential to be lead compounds for future antitubercular drug discovery.

Microwave assisted synthesis of disubstituted imidazo[1,2-a]pyridine-3-carboxylic acid esters

A novel and efficient synthetic method leveraging microwave-assisted organic synthesis (MAOS) to prepare disubstituted imidazo[1,2-a]- pyridine-3-carboxylic acid esters (IPCEs) (3a-z), the key intermediates for a class of novel anti-tuberculosis agents, is reported. Under microwave heating at 120 °C for 20 or 30 min, the condensations of 2-aminopyridines (1a-k) and ethyl 2-halogenated acetoacetates (2a-d) were conveniently performed in ethanol with acceptable yields.