885276-59-5

Usage

Uses

Used in Pharmaceutical Synthesis:
1-Bromo-imidazo[1,5-a]pyridine-3-carboxylic acid ethyl ester is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of biologically active compounds. Its unique structure allows for the creation of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 1-Bromo-imidazo[1,5-a]pyridine-3-carboxylic acid ethyl ester is used as a precursor in the production of agrochemicals, such as pesticides and herbicides, due to its potential to enhance the effectiveness of these compounds.
Used in Dye Manufacturing:
1-Bromo-imidazo[1,5-a]pyridine-3-carboxylic acid ethyl ester is utilized as a building block in the manufacturing of dyes, where its chemical properties contribute to the creation of dyes with specific color characteristics and stability.
Used in Medicinal Chemistry and Drug Discovery:
1-BROMO-IMIDAZO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER is also used as a research tool in medicinal chemistry and drug discovery, where its structural features can be exploited to design and develop new therapeutic agents with improved pharmacological properties. Its potential applications in this field highlight its versatility and importance in the advancement of medical treatments.

Upstream product

• 81803-60-3 ethyl imidazo<1,5-a>pyridine-3-carboxylate 
• 46460-25-7 ethyl 2-oxo-2-((pyridin-2-ylmethyl)amino)acetate 
• 3731-51-9 2-(Aminomethyl)pyridine 

Downstream Products

• 1039356-90-5 ethyl 1-(4-fluorophenyl)imidazo[1,5-a]pyridine-3-carboxylate 

Relevant academic research and scientific papers

Fragment-based drug discovery of potent and selective MKK3/6 inhibitors

The MAPK signaling cascade, comprised of several linear and intersecting pathways, propagates signaling into the nucleus resulting in cytokine and chemokine release. The Map Kinase Kinase isoforms 3 and 6 (MKK3 and MKK6) are responsible for the phosphorylation and activation of p38, and are hypothesized to play a key role in regulating this pathway without the redundancy seen in downstream effectors. Using FBDD, we have discovered efficient and selective inhibitors of MKK3 and MKK6 that can serve as tool molecules to help further understand the role of these kinases in MAPK signaling, and the potential impact of inhibiting kinases upstream of p38.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over- activation of NF-kB signaling is observed.

IMIDAZOPYRIDINE ANALOGS AS CB2 RECEPTOR MODULATORS, USEFUL IN THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES

The present invention relates to compounds represented by Formula (I) and Formula (II): (I) (II) or pharmaceutically acceptable salts thereof. The present invention also provides pharmaceutical compositions comprising the instant compounds. This invention further provides methods to treat and prevent pain, respiratory and non-respiratory diseases.