885277-95-2 Usage
Uses
Used in Pharmaceutical Industry:
3-CBZ-AMINO-BUTYLAMINE is used as a reagent in the synthesis of pharmaceuticals for its role in creating new drug candidates. Its unique chemical properties allow for the development of innovative therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 3-CBZ-AMINO-BUTYLAMINE is utilized as a reagent for the production of agrochemicals, contributing to the creation of new compounds that can enhance crop protection and yield.
Used in Polymer and Material Science:
3-CBZ-AMINO-BUTYLAMINE is used as a building block in the production of polymers and materials, where it can impart specific characteristics to these substances, potentially improving their performance in various applications.
Used in Drug Development and Medicinal Chemistry:
Due to its potential to alter molecular properties, 3-CBZ-AMINO-BUTYLAMINE is employed as a key component in drug development and medicinal chemistry, facilitating the design and synthesis of novel therapeutic agents.
Used as a Research Tool in Chemical and Biological Studies:
3-CBZ-AMINO-BUTYLAMINE also serves as a research tool in chemical and biological studies, leveraging its unique chemical and structural properties to advance scientific understanding and discovery in these fields.
Check Digit Verification of cas no
The CAS Registry Mumber 885277-95-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,2,7 and 7 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 885277-95:
(8*8)+(7*8)+(6*5)+(5*2)+(4*7)+(3*7)+(2*9)+(1*5)=232
232 % 10 = 2
So 885277-95-2 is a valid CAS Registry Number.
885277-95-2Relevant academic research and scientific papers
Terzi?, Natasa,Konstantinovi?, Jelena,Tot, Miklo?,Burojevi?, Jovana,Djurkovi?-Djakovi?, Olgica,Srbljanovi?, Jelena,?tajner, Tijana,Verbi?, Tatjana,Zlatovi?, Mario,Machado, Marta,Albuquerque, Inês S.,Prudêncio, Miguel,Sciotti, Richard J.,Pecic, Stevan,D'Alessandro, Sarah,Taramelli, Donatella,?olaja, Bogdan A.
, p. 264 - 281 (2016)
The syntheses and antiplasmodial activities of various substituted aminoquinolines coupled to an adamantane carrier are described. The compounds exhibited pronounced in vitro and in vivo activity against Plasmodium berghei in the Thompson test. Tethering a fluorine atom to the aminoquinoline C(3) position afforded fluoroaminoquinolines that act as intrahepatocytic parasite inhibitors, with compound 25 having an IC50 = 0.31 μM and reducing the liver load in mice by up to 92% at 80 mg/kg dose. Screening our peroxides as inhibitors of liver stage infection revealed that the tetraoxane pharmacophore itself is also an excellent liver stage P. berghei inhibitor (78: IC50 = 0.33 μM). Up to 91% reduction of the parasite liver load in mice was achieved at 100 mg/kg. Examination of tetraoxane 78 against the transgenic 3D7 strain expressing luciferase under a gametocyte-specific promoter revealed its activity against stage IV-V Plasmodium falciparum gametocytes (IC50 = 1.16 ± 0.37 μM). To the best of our knowledge, compounds 25 and 78 are the first examples of either an 4-aminoquinoline or a tetraoxane liver stage inhibitors.
