885278-98-8

Basic information

• Product Name: ETHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE
• Synonyms: ETHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE
• CAS NO: 885278-98-8
• Molecular Formula: C11H12N2O3
• Molecular Weight: 220.22
• Mol File: 885278-98-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE(885278-98-8)
• EPA Substance Registry System: ETHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE(885278-98-8)

Safety Data

• Hazardous Substances Data: 885278-98-8(Hazardous Substances Data)

Usage

General Description

ETHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE is a chemical compound with the molecular formula C12H12N2O3. It is an indazole derivative, which is a class of chemical compounds known for their diverse biological activities. This particular compound is used in the field of medicinal chemistry and drug discovery for its potential pharmacological properties. Its precise application and use may vary, but it is commonly utilized as a building block for the synthesis of various biologically active molecules, such as pharmaceutical drugs and agrochemicals. The compound's structure and properties make it a valuable tool for researchers and scientists in the development of new medications and agricultural products.

Upstream product

• 1210745-38-2 ethyl 7-methoxy-2-{[(2-trimethylsilyl)ethoxy]methyl}-2H-indazole-3-carboxylate 
• 623-73-4 diazoacetic acid ethyl ester 
• 217813-03-1 3-methoxy-2-(trimethylsilyl)phenyl-trifluoromethanesulfonate 

Relevant articles and documents

High-affinity fluorescent ligands for the 5-HT3 receptor

The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT3 receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT3AR.

Facile and efficient synthesis of indazole derivatives by 1,3-cycloaddition of arynes with diazo compounds and azomethine imides

N-Unsubstituted indazoles 3 and 1-arylindazoles 4 are readily available in good to high yields through [3+2] cycloaddition of 2-(trimethylsilyI)aryl triflates 1 and diazo compounds in the presence of KF or CsF under mild reaction conditions. Furthermore, we found that azomethine imides also underwent cycloaddition reaction with 2-(trimethylsilyl)phenyl triflates (la) in the presence of KF to afford indazolone derivatives 6 in moderate yields.

An efficient, facile, and general synthesis of 1H-indazoles by 1,3-dipolar cycloaddition of arynes with diazomethane derivatives

(Chemical Equation Presented) Take your pick: Both N-unsubstituted and 1-aryl 1H-indazoles are available in good to high yields through the [3+2] cycloaddition of benzynes derived from o-silylaryl triflates with diazomethane derivatives (see scheme). In the presence of KF/[18]crown-6, the N-unsubstituted 1H-indazole is formed, whereas the 1-arylated product is obtained regioselectively with CsF and an excess of the triflate.