885280-53-5

Basic information

• Product Name: [2-(3-METHOXY-PHENYL)-THIAZOL-4-YL]-METHANOL
• Synonyms: [2-(3-METHOXY-PHENYL)-THIAZOL-4-YL]-METHANOL
• CAS NO: 885280-53-5
• Molecular Formula: C₁₁H₁₁NO₂S
• Molecular Weight: 221.28
• Mol File: 885280-53-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [2-(3-METHOXY-PHENYL)-THIAZOL-4-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(3-METHOXY-PHENYL)-THIAZOL-4-YL]-METHANOL(885280-53-5)
• EPA Substance Registry System: [2-(3-METHOXY-PHENYL)-THIAZOL-4-YL]-METHANOL(885280-53-5)

Safety Data

• Hazardous Substances Data: 885280-53-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
[2-(3-Methoxy-phenyl)-thiazol-4-yl]-methanol is used as a pharmaceutical research compound for its potential antimicrobial and antifungal properties. Its unique structure allows it to be a candidate for the development of new drugs targeting various infections.
Used in Organic Synthesis:
[2-(3-Methoxy-phenyl)-thiazol-4-yl]-methanol is used as a chemical intermediate in organic synthesis. Its versatile structure makes it a valuable component in the creation of more complex organic molecules for various applications.
Used in Medicinal Chemistry:
[2-(3-Methoxy-phenyl)-thiazol-4-yl]-methanol is used as a building block in medicinal chemistry for designing and developing new therapeutic agents. Its unique combination of functional groups and its thiazole core contribute to its potential as a key component in novel drug discovery.

Upstream product

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Relevant articles and documents

Single-step microwave-mediated synthesis of oxazoles and thiazoles from 3-oxetanone: A synthetic and computational study

The direct microwave-mediated condensation between 3-oxetanone and primary amides and thioamides has delivered moderate to good yields of (hydroxymethyl)oxazoles and (hydroxymethyl)thiazoles. The reactions use a sustainable solvent and only require short reaction times. These are highly competitive methods for the construction of two classes of valuable heteroarenes, which bear a useful locus for further elaboration. Electronic structure calculations have shown that the order of events involves chalcogen atom attack at sp3 carbon and alkyl-oxygen cleavage. The critical role of acid catalysis was shown clearly, and the importance of acid strength was demonstrated. The calculated barriers were also fully consistent with the observed order of thioamide and amide reactivity. Spontaneous ring opening involves a modest degree of C-O cleavage, moderating the extent of strain relief. On the acid-catalysed pathway, C-O cleavage is less extensive still, but proton transfer to the nucleofuge is well advanced with the carboxylic acid catalysts, and essentially complete with methanesulfonic acid. Open sesame: The direct microwave-mediated condensation between 3-oxetanone and primary amides and thioamides has delivered moderate to good yields of oxazoles and thiazoles. The reactions use a sustainable solvent, require only short reaction times and represent a highly competitive method for the construction of two classes of valuable heteroarenes. Electronic structure calculations have been used to probe a range of potential reaction mechanisms (see figure). Copyright