885318-83-2Relevant academic research and scientific papers
Synthesis of enantiopure 2-amino-1-phenyl and 2-amino-2-phenyl ethanols using enantioselective enzymatic epoxidation and regio- and diastereoselective chemical aminolysis
Sello, Guido,Orsini, Fulvia,Bernasconi, Silvana,Gennaro, Patrizia Di
, p. 372 - 376 (2007/10/03)
Several enantiopure 1,2-amino alcohols have been prepared by combining a stereoselective enzymatic epoxidation of styrenes with regio- and stereoselective chemical reactions. An interesting reactivity has been noted concerning the reaction of epoxides and NH3 under microwave activation.
Designing new chiral ketone catalysts. Asymmetric epoxidation of cis-olefins and terminal olefins
Tian, Hongqi,She, Xuegong,Yu, Hongwu,Shu, Lianhe,Shi, Yian
, p. 2435 - 2446 (2007/10/03)
This paper describes a new class of chiral oxazolidinone ketone catalyst for asymmetric epoxidation. High ee values have been obtained for a number of cyclic and acyclic cis-olefins. The epoxidation was stereospecific with no isomerization observed in the epoxidation of acyclic systems. Encouragingly high ee values have also been obtained for a number of terminal olefins. Mechanistic studies show that electronic interactions play an important role in stereodifferentiation.
