885428-60-4 Usage
Description
α-(1-Methoxypropylidene)-4-nitro-benzeneacetonitrile is an organic compound that serves as an important intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is characterized by its unique structure, which includes a nitro group, a cyano group, and a methoxypropylidene group attached to a benzene ring. α-(1-Methoxypropylidene)-4-nitro-benzeneacetonitrile plays a crucial role in the development of new drugs and agrochemicals due to its versatile reactivity and functional groups.
Uses
Used in Pharmaceutical Industry:
α-(1-Methoxypropylidene)-4-nitro-benzeneacetonitrile is used as a key intermediate in the synthesis of 2,4-diaminopyrimidine growth hormone secretagogue receptor antagonists. These antagonists are important for the development of drugs that can modulate the activity of growth hormone secretagogue receptors, which play a significant role in the regulation of growth hormone release and energy homeostasis. α-(1-Methoxypropylidene)-4-nitro-benzeneacetonitrile's unique structure and reactivity make it an ideal candidate for the synthesis of these biologically active molecules.
Used in Agrochemical Industry:
In addition to its applications in the pharmaceutical industry, α-(1-Methoxypropylidene)-4-nitro-benzeneacetonitrile can also be used in the agrochemical industry for the development of new pesticides and herbicides. Its versatile functional groups and reactivity allow for the synthesis of a wide range of agrochemicals with different modes of action and selectivity profiles. This can lead to the discovery of novel and more effective crop protection agents that can help address the challenges of pest resistance and crop yield.
Check Digit Verification of cas no
The CAS Registry Mumber 885428-60-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,4,2 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 885428-60:
(8*8)+(7*8)+(6*5)+(5*4)+(4*2)+(3*8)+(2*6)+(1*0)=214
214 % 10 = 4
So 885428-60-4 is a valid CAS Registry Number.
885428-60-4Relevant articles and documents
2,4-Diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists
Serby, Michael D.,Zhao, Hongyu,Szczepankiewicz, Bruce G.,Kosogof, Christi,Xin, Zhili,Liu, Bo,Liu, Mei,Nelson, Lissa T. J.,Kaszubska, Wiweka,Falls, H. Douglas,Schaefer, Verlyn,Bush, Eugene N.,Shapiro, Robin,Droz, Brian A.,Knourek-Segel, Victoria E.,Fey, Thomas A.,Brune, Michael E.,Beno, David W. A.,Turner, Theresa M.,Collins, Christine A.,Jacobson, Peer B.,Sham, Hing L.,Liu, Gang
, p. 2568 - 2578 (2007/10/03)
Ghrelin, a gut-derived orexigenic hormone, is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R). Centrally administered ghrelin has been shown to cause hunger and increase food intake in rodents. Inhibition of ghrelin actions with ghrelin antibody, peptidyl GHS-R antagonists, and antisense oligonucleosides resulted in weight loss and food intake decrease in rodents. Here we report the effects of GHS-R antagonists, some of which were potent, selective, and orally bioavailable. A structure-activity relationship study led to the discovery of 8a, which was effective in decreasing food intake and body weight in several acute rat studies.
