885453-50-9

Upstream product

• 107-13-1 acrylonitrile 
• 583-75-5 4-Bromo-2-methylaniline 

Downstream Products

• 1609686-91-0 4-{6-[4-(2-cyanovinyl)-2-methylphenylamino]-3-fluoropyridin-2-ylamino}benzonitrile 
• 1609687-22-0 4-{6-[4-(2-cyanovinyl)-2-methylphenylamino]-3-fluoropyridin-2-ylamino}benzonitrile 
• 1609686-87-4 (E)-3-{4-[6-(4-chlorophenyl)amino-5-fluoropyridin-2-ylamino]-3-methylphenyl}acrylonitrile 
• 1609686-90-9 (E)-3-(4-{5-fluoro-6-[(4-fluorophenyl)amino]pyridin-2-ylamino}-3-methylphenyl)acrylonitrile 
• 1609687-03-7 4-{5-[4-(2-cyanovinyl)-2-methylphenylamino]-2-fluorophenylamino}benzonitrile 
• 1609687-31-1 4-{5-[4-(2-cyanovinyl)-2-methylphenylamino]-2-fluorophenylamino}benzonitrile 
• 1207204-89-4 C₂₂H₁₅F₃N₆O₃S 

Relevant academic research and scientific papers

2,6-Di(arylamino)-3-fluoropyridine Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors

New non-nucleoside reverse transcriptase inhibitors (NNRTI), which are similar in structure to earlier described di(arylamino)pyrimidines but featuring a 2,6-di(arylamino)-3-fluoropyridine, 2,4-di(arylamino)-5-fluoropyrimidine, or 1,3-di(arylamino)-4-fluorobenzene moiety instead of a 2,4-disubstituted pyrimidine moiety, are reported. The short and practical synthesis of novel NNRTI relies on two sequential Pd-catalyzed aminations as the key steps. It is demonstrated through direct comparison with reference compounds that the presence of a fluorine atom increases the in vitro anti-HIV activity, both against the wild type virus and drug-resistant mutant strains.

NOVEL ANTI-HIV COMPOUNDS

The present invention relates to the field of HIV-1 infections, and in particular provides novel compounds containing fluorine on the Central ring. The compounds according to this invention are very suitable for the prevention and/or treatment of HIV-1 infection and in particular show higher activity against NNRTI-resistant strains of HIV-1.