88546-83-2

Upstream product

• 80594-26-9 (+)-(1S,2S,3S)-t-2-phenyl-1,2,c-3-trideuteriocyclopropylmethanol 
• 80594-21-4 (+)-(1S,2S,3S)-t-2-phenyl-1,2,c-3-trideuteriocyclopropanecarboxylic acid 
• 80594-22-5 methyl (+)-(1S,2S,3S)-t-2-phenyl-1,2,c-3-trideuteriocyclopropanecarboxylate 
• 52751-11-8 cis<α,β-2H2>styrene 

Downstream Products

• 88546-86-5 (2R,3R)-1-phenyl-r-1,c-2,t-3-trideuteriocyclopropane 

Relevant academic research and scientific papers

Efficient syntheses of four chiral phenylcyclopropanes

An efficient four-step synthetic route from each of four crystalline isotopically labeled (1R)-menthyl (1S,2S)-(+)-2-phenylcyclopropanecarboxyates of better than 99% enantiomeric excess has provided multi-gram quantities of the corresponding chiral phenylcyclopropanes. The key transformation involved a bis[1,3-bis(diphenylphosphino)propane]rhodium chloride that catalyzed a highly stereoselective decarbonylation of a trans-2-phenylcyclopropanecarboxaldehyde.

Stereochemical Kinetics of the Thermal Stereomutations Interconverting Achiral Isomers of 1-Phenyl-1,2,3-trideuteriocyclopropane

All three achiral forms of 1-phenyl-1,2,3-trideuteriocyclopropane have been synthesized with high stereochemical integrity, and the thermal stereomutations among them have been followed at 309.3 deg C in the gas phase by Raman and 1H NMR spectroscopy.The