885463-80-9Relevant academic research and scientific papers
An efficient and convenient synthesis of heterocycle-fused indazoles via the N-N bond forming reaction of nitroarenes induced by low-valent titanium reagent
Lin, Wei,Hu, Ming-Hua,Feng, Xian,Cao, Cheng-Pao,Huang, Zhi-Bin,Shi, Da-Qing
, p. 6721 - 6726 (2013/07/26)
A mild and efficient one-pot protocol for the preparation of 8,13-dihydro-7H-indolo[2′,3′:3,4]pyrido[1,2-b]indazole and 5,6-dihydroindazolo[3,2-a]isoquinoline via the reductive cyclization of nitro-aryl substrates mediated by a low-valent titanium reagent has been developed. The attractive features of the current method include an N-N bond formation and the selective reduction of the CN bond and nitro group, both of which were easily achieved in one-pot by controlling the pH of the reaction mixture.
Unprecedented SnCl2-mediated cyclization of nitro arenes via N-N bond formation
Sawant, Devesh,Kumar, Rishi,Maulik, Prakas R.,Kundu, Bijoy
, p. 1525 - 1528 (2007/10/03)
A mild, efficient, one-pot protocol for the cyclization of nitro-aryl substrates using SnCl2 has been described. The mechanistic course of the reaction suggests the involvement of a hydroxylamine intermediate leading to an intramolecular cyclization via N-N bond formation. The versatility of the methodology has been demonstrated by using two nitro-aryl substrates derived from dihydroisoquinolines and dihydro-β-carbolines. The intramolecular cyclization led to the formation of indazoles in high yields and purities.
