88549-64-8

Upstream product

• 27854-88-2 (R)-1-(4-pyridinyl)ethanol 
• 90-27-7 2-Phenylbutyric acid 
• 54656-96-1 (S)-1-(4-pyridyl)ethanol 
• 1519-21-7 2-phenylbutyric anhydride 

Relevant academic research and scientific papers

Kinetic Resolution of Racemic Carboxylic Acids and Alcohols with Homochiral Alcohols and Carboxylic Acids, Respectively, and the Mukaiyama or Palomo Reagents

The Mukaiyama and Palomo reagents have been used for the kinetic resolution of racemic carboxylic acids or alcohols with homochiral alcohols or carboxylic acids, respectively, in the presence of triethylamine.Thus, enantiomerically enriched carboxylic acids (e.e.68percent), alcohols (e.e.41percent) or diastereoisomerically enriched esters (d.e.84percent) are obtained.

Kinetic resolution of racemic carboxylic acids with homochiral alcohols and dicyclohexylcarbodiimide

Racemic carboxylic acids have been kinetically resolved by means of homochiral alcohols using the DCC-esterification methodology. The best results were obtained with commercially available homochiral 1-(4-pyridyl)ethanol: 60% e.e. for enantiomerically enriched acids and 76% d.e. for diastereomerically enriched esters.