885495-07-8Relevant academic research and scientific papers
Discovery of S-777469: An orally available CB2 agonist as an antipruritic agent
Odan, Masahide,Ishizuka, Natsuki,Hiramatsu, Yoshiharu,Inagaki, Masanao,Hashizume, Hiroshi,Fujii, Yasuhiko,Mitsumori, Susumu,Morioka, Yasuhide,Soga, Masahiko,Deguchi, Masashi,Yasui, Kiyoshi,Arimura, Akinori
, p. 2803 - 2806 (2012/05/20)
The discovery of novel CB2 ligands based on the 3-carbamoyl-2-pyridone derivatives by adjusting the size of side chain at 1-, 5- and 6-position is reported. The structure-activity relationship around this template lead to the identification of S-777469 as a selective CB2 receptor agonist, which exhibited the significant inhibition of scratching induced by Compound 48/80 at 1.0 mg/kg po and 10 mg/kg po (55% and 61%, respectively).
