88550-34-9Relevant academic research and scientific papers
BIASED POTENT OPIOID-LIKE AGONISTS AS IMPROVED MEDICATIONS TO TREAT CHRONIC AND ACUTE PAIN AND METHODS OF USING THE SAME
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Paragraph 00148, (2019/10/15)
The present invention is directed to a compound having Formula (I) and its enantiomer: wherein the definitions of n, R, X, Y and Y3, and Z are provided in the disclosure. The invention is also directed to pharmaceutical compositions of the disc
Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure - Activity relationships of a potent μ-agonist δ-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan
Hiebel, Anne-Cécile,Yong, Sok Lee,Bilsky, Edward,Giuvelis, Denise,Deschamps, Jeffrey R.,Parrish, Damon A.,Aceto, Mario D.,May, Everette L.,Harris, Louis S.,Coop, Andrew,Dersch, Christina M.,Partilla, John S.,Rothman, Richard B.,Cheng, Kejun,Jacobson, Arthur E.,Rice, Kenner C.
, p. 3765 - 3776 (2008/03/11)
Both of the enantiomers of 5-(3-hydroxyphenyl)-N-phenylethylmorphan with C9α-methyl, C9-methylene, C9-keto, and C9α- and C9β-hydroxy substituents were synthesized and pharmacologically evaluated. Three of the 10 compounds, (1R,5R,9S)-(-)-9-hydroxy-5-(3-hy
