885517-77-1Relevant articles and documents
Development of a new practical synthesis of a 5-HT2C receptor agonist
Gontcharov, Alexander,Potoski, John,Khafizova, Gulnaz,Shaw, Chia-Cheng,Yu, Qing,Tadayon, Sam,Bernatchez, Michel,Lankau, Mark,Cantin, Michel,Stack, Gary,Gross, Jonathan,Zhou, Dahui
scheme or table, p. 1438 - 1447 (2011/09/20)
A new practical synthesis of a 5-HT2C receptor agonist has been developed and implemented on multikilogram scale. The key step, the selective epoxide opening in the glycidyl tosylate with the aryl Grignard reagent, allowed the incorporation of this commercially available chiral C3 synthon into the molecule and elaboration of the resulting intermediate into the target aminomethyldihydrobenzofuran without loss of enantiomeric purity.
BENZOXATHIINE AND BENZOXATHIOLE DERIVATIVES AND USES THEREOF
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Page/Page column 47-48; 55, (2008/12/05)
Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided, wherein each of R1, R2, R3, R4, y, n, m, p, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF
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Page/Page column 95, (2010/11/24)
Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R2, R3, R4, y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
