885519-14-2 Usage
Uses
Used in Pharmaceutical and Medicinal Chemistry:
3-Chloro-5-iodo (1H)indazole is employed as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications, making it an essential component in medicinal chemistry research.
Used in the Development of New Materials and Chemical Processes:
3-CHLORO-5-IODO (1H)INDAZOLE is utilized as a building block in the creation of novel materials and chemical processes. Its presence in these applications can lead to advancements in material science and chemical engineering, contributing to the development of innovative products and technologies.
Used in Organic Chemistry Research:
3-Chloro-5-iodo (1H)indazole serves as a valuable tool for scientific investigation and experimentation in the field of organic chemistry. Its unique properties and reactivity make it an ideal candidate for studying various chemical reactions and mechanisms, furthering our understanding of organic chemistry principles.
Check Digit Verification of cas no
The CAS Registry Mumber 885519-14-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,5,1 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 885519-14:
(8*8)+(7*8)+(6*5)+(5*5)+(4*1)+(3*9)+(2*1)+(1*4)=212
212 % 10 = 2
So 885519-14-2 is a valid CAS Registry Number.
885519-14-2Relevant academic research and scientific papers
Iodoindazoles with Selective Magnesiation at Position 3: A Route to Highly Functionalized Indazoles
Lam, Bao Vy,Berhault, Yohann,Stiebing, Silvia,Fossey, Christine,Cailly, Thomas,Collot, Valérie,Fabis, Frédéric
supporting information, p. 4440 - 4446 (2016/03/22)
A unique route to highly functionalized indazoles is described. A regioselective magnesiation at position 3 of 4-, 5-, 6- and 7-iodo-2-THP-indazoles (THP=tetrahydropyranyl) has been developed using TMPMgClLiCl (TMP=2,2,6,6-tetramethylpiperidyl). The obtained magnesiate can be trapped by different electrophiles to introduce a wide range of functional groups including halogens, thioalkyls, alcohols, aldehydes, ketones, amides, or esters at position 3. Once this position is functionalized, the iodine atoms can be further reacted through metal-halogen exchange or cross-coupling strategies. Finally, N-substitution reactions allow the synthesis of a variety of highly functionalized indazoles giving access to these valuable scaffolds through a simple and unique route.
