885520-29-6 Usage
Description
6-CHLORO-4-FLUORO (1H)INDAZOLE is a chemical compound belonging to the indazole family, characterized by the molecular formula C7H4ClFN. It features a chlorine atom at the 6th position and a fluorine atom at the 4th position, which contribute to its unique chemical properties. 6-CHLORO-4-FLUORO (1H)INDAZOLE is significant in the field of organic chemistry due to its potential biological activities and its role as a building block for developing new therapeutic agents.
Uses
Used in Pharmaceutical Industry:
6-CHLORO-4-FLUORO (1H)INDAZOLE is utilized as an intermediate in the synthesis of various bioactive molecules, including drugs and agrochemicals. Its chemical structure and properties make it a valuable component in the development of new therapeutic agents, particularly for research and development applications.
Check Digit Verification of cas no
The CAS Registry Mumber 885520-29-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,5,2 and 0 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 885520-29:
(8*8)+(7*8)+(6*5)+(5*5)+(4*2)+(3*0)+(2*2)+(1*9)=196
196 % 10 = 6
So 885520-29-6 is a valid CAS Registry Number.
885520-29-6Relevant articles and documents
Development of a late-stage diversification strategy for the 4- And 5-Positions of 4,5,6-trisubstituted indazoles
Barber, Joyann S.,Burtea, Alexander,Collins, Michael R.,Tran-Dube, Michelle,Patman, Ryan L.,Scales, Stephanie,Smith, Graham,Spangler, Jillian E.,Wang, Fen,Wang, Wei,Yang, Shouliang,Zhu, JinJiang,Patrick Montgomery
supporting information, p. 9047 - 9052 (2020/11/30)
Indazoles represent a privileged motif in drug discovery. However, the formation of highly substituted indazoles can require the execution of lengthy synthetic routes with minimal opportunities to introduce diversity. In this report, we disclose the development of a late-stage diversification strategy for the 4- and 5-positions of 4,5,6-trisubstituted indazoles. A regioselective C-H functionalization and subsequent nucleophilic aromatic substitution provide two sequential points of diversification. The synthetic sequence delivers rapid access to an array of 4,5,6-trisubstituted indazoles in only four steps from readily available starting materials.
