885520-49-0 Usage
Uses
Used in Pharmaceutical Synthesis:
1H-Indole, 6-fluoro-4-iodois used as a key intermediate in the synthesis of pharmaceuticals for its ability to participate in various chemical reactions, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Development:
In the agrochemical industry, 1H-Indole, 6-fluoro-4-iodois utilized as a precursor in the creation of novel compounds designed to enhance crop protection and management, leveraging its unique structural features to improve the effectiveness of these products.
Used in Medicinal Chemistry Research:
1H-Indole, 6-fluoro-4-iodoserves as an important subject in medicinal chemistry research, where its fluorine and iodine atoms are of particular interest. The study of 1H-Indole, 6-fluoro-4-iodo- aids in understanding the impact of halogen substitution on molecular properties and interactions, which is crucial for the design of more effective and targeted drugs.
Used in Organic Chemistry:
As a derivative of indole with specific halogens, 1H-Indole, 6-fluoro-4-iodois employed in organic chemistry for its potential to undergo a range of reactions, facilitating the synthesis of complex organic molecules for various applications, including materials science and specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 885520-49-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,5,2 and 0 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 885520-49:
(8*8)+(7*8)+(6*5)+(5*5)+(4*2)+(3*0)+(2*4)+(1*9)=200
200 % 10 = 0
So 885520-49-0 is a valid CAS Registry Number.
885520-49-0Relevant articles and documents
In search of simplicity and flexibility: A rational access to twelve fluoroindolecarboxylic acids
Schlosser, Manfred,Ginanneschi, Assunta,Leroux, Frederic
, p. 2956 - 2969 (2007/10/03)
All twelve indolecarboxylic acids 1-12 carrying both a fluorine substituent and a carboxy group at the benzo ring have been prepared either directly from the corresponding fluoroindoles 13-16 or from the chlorinated derivatives 22, 23 and 25 by hydrogen/metal permutation ("metalation"), or from the bromo- or iodofluoroindoles 17-20 and 26, 27, 29 and 30 by halogen/metal permutation, the organometallic intermediate being each time trapped with carbon dioxide. In most, though not all cases, the nitrogen atom in the five-membered ring had to be protected by a trialkylsilyl group. Some of the bromo- or iodofluoroindoles (26 and 27) were successfully subjected to a basicity gradient-driven selective migration of the heavy halogen. An unexpected finding on the way to the target compounds were the rigorously site-selective metalation of the 5-fluoro-N-(trialkylsilyl)indole (14b; exclusive deprotonation of the 4-position). The fluoroindoles 13-16, although previously known, were accessed more conveniently from suitably substituted nitrobenzenes using the Bartoli or the Leimgruber-Batcho method. A new and very attractive indole synthesis was elaborated consisting of the ortho-lithiation of an N-acyl-protected aniline followed by ortho-formylation, Wittig chloromethylenation and base-catalyzed cyclization accompanied by dehydrochlorination. These five consecutive steps can be contracted to a convenient one-pot protocol. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
