885521-84-6 Usage
Description
3,6-DIBROMO (1H)INDAZOLE is a chemical compound with the molecular formula C8H5Br2N. It is a derivative of indazole, a heterocyclic compound with a five-membered ring containing three carbon atoms and two nitrogen atoms. 3,6-DIBROMO (1H)INDAZOLE is characterized by the presence of two bromine atoms at the 3rd and 6th positions, which give it unique chemical properties. It is a yellow-brown colored solid at room temperature and is known for its potential applications in the field of medicinal chemistry, particularly in the development of new drugs and therapeutic agents.
Uses
Used in Pharmaceutical Synthesis:
3,6-DIBROMO (1H)INDAZOLE is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique chemical properties make it a valuable building block for the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry Research:
3,6-DIBROMO (1H)INDAZOLE is used as a research compound in medicinal chemistry. Its potential biological activities and unique chemical properties make it an interesting subject for researchers working on the discovery and development of new drugs and therapeutic agents.
Used in Drug Development:
3,6-DIBROMO (1H)INDAZOLE is used in the development of new drugs and therapeutic agents. Its unique chemical properties and potential biological activities make it a promising candidate for the treatment of various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 885521-84-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,5,2 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 885521-84:
(8*8)+(7*8)+(6*5)+(5*5)+(4*2)+(3*1)+(2*8)+(1*4)=206
206 % 10 = 6
So 885521-84-6 is a valid CAS Registry Number.
885521-84-6Relevant articles and documents
Bromide-assisted chemoselective Heck reaction of 3-bromoindazoles under high-speed ball-milling conditions: Synthesis of axitinib
Yu, Jingbo,Hong, Zikun,Yang, Xinjie,Jiang, Yu,Jiang, Zhijiang,Su, Weike
, p. 786 - 795 (2018)
A mechanically-activated chemoselective Heck coupling for the synthesis of 3-vinylindazoles has been developed with the aid of catalytic amounts of TBAB and NaBr as both dehalogenation restrainer and grinding auxiliary. After tuning of the chemical conditions and mechanical parameters, a series of non-activated 3-bromoindazoles and a broad scope of olefins worked well to give the corresponding coupling products in good to excellent yields. A further application of this protocol was performed in a two-step mechanochemical Heck/Migita cross coupling, which provided a highly efficient route for the synthesis of axitinib.
