885524-81-2

Usage

Uses

Used in Pharmaceutical Research:
(5-Methoxy-1H-indol-1-yl)acetic acid is used as a research tool for studying the regulation and synthesis of serotonin in the brain. Its role in understanding the neurotransmitter's pathways and mechanisms is crucial for developing potential therapeutic applications.
Used in Drug Development:
In the pharmaceutical industry, (5-Methoxy-1H-indol-1-yl)acetic acid is used as a starting material for the development of new drugs aimed at treating neurological and psychiatric disorders. Its influence on serotonin levels makes it a promising candidate for therapeutic interventions in conditions related to neurotransmitter imbalances.
Used in Chemical Synthesis:
(5-Methoxy-1H-indol-1-yl)acetic acid is also employed as an intermediate in the synthesis of various chemical compounds, particularly those related to the indole family, which have diverse applications in the chemical, pharmaceutical, and materials science industries.

Upstream product

• 885524-56-1 methyl 2-(5-methoxy-1H-indol-1-yl)acetate 
• 885524-85-6 C₁₃H₁₅NO₃ 
• 1006-94-6 5-methoxylindole 

Downstream Products

• 1351767-63-9 C₂₆H₂₆F₄N₂O₆ 
• 1351767-55-9 (S)-3-(2-(5-methoxy-1H-indol-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid 
• 1351767-75-3 C₂₆H₃₀F₂N₂O₆ 
• 1351767-71-9 C₂₆H₂₈F₄N₂O₆ 

Relevant academic research and scientific papers

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

Compounds, pyridine N-oxides, and pharmaceutically acceptable salts of formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and for preventing and/ or treating diseases of the respiratory tract characterized by airway obstruction, such as asthma or COPD.

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

Virtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitors

Proteolytic cleavage of amyloid precursor protein by β-secretase (BACE1) is a key step in generating the N-terminal of β-amyloid (Aβ), which further forms into amyloid plaques that are considered as the hallmark of Alzheimer's disease. Inhibitors of BACE1 can reduce the levels of Aβ and thus have a therapeutic potential for treating the disease. We report here the identification of a series of small molecules bearing an indole acylguanidine core structure as potent BACE1 inhibitors. The initial weak fragment was discovered by virtual screening, and followed with a hit-to-lead optimization. With the aid of co-crystal structures of two discovered inhibitors (compounds 19 and 25) with BACE1, we explored the SAR around the indole and aryl groups, and obtained several BACE1 inhibitors about 1,000-fold more potent than the initial fragment hit. Accompanying the lead optimization, a previously under-explored sub-site opposite the flap loop was redefined as a potential binding site for later BACE1 inhibitor design.

Synthesis and evaluation of indole aspartyl ketones as novel caspase-3 inhibitors

Synthesis, biological evaluation and structure-activity relationships for a series of novel nonpeptide small molecule inhibitors of caspase-3 are described. Among the synthesized compounds, 2,3,5,6-tetrafluorophenoxymethyl ketone derivatives of indole-N-a