885524-81-2 Usage
Description
(5-Methoxy-1H-indol-1-yl)acetic acid, also known as 5-MeO-IAA, is a chemical compound with the molecular formula C11H11NO4. It is a derivative of indole and features a methoxy group attached to the 5 position of the indole ring. (5-Methoxy-1H-indol-1-yl)acetic acid serves as a precursor to the neurotransmitter serotonin and is predominantly utilized in research to investigate the regulation and synthesis of serotonin in the brain.
Uses
Used in Pharmaceutical Research:
(5-Methoxy-1H-indol-1-yl)acetic acid is used as a research tool for studying the regulation and synthesis of serotonin in the brain. Its role in understanding the neurotransmitter's pathways and mechanisms is crucial for developing potential therapeutic applications.
Used in Drug Development:
In the pharmaceutical industry, (5-Methoxy-1H-indol-1-yl)acetic acid is used as a starting material for the development of new drugs aimed at treating neurological and psychiatric disorders. Its influence on serotonin levels makes it a promising candidate for therapeutic interventions in conditions related to neurotransmitter imbalances.
Used in Chemical Synthesis:
(5-Methoxy-1H-indol-1-yl)acetic acid is also employed as an intermediate in the synthesis of various chemical compounds, particularly those related to the indole family, which have diverse applications in the chemical, pharmaceutical, and materials science industries.
Check Digit Verification of cas no
The CAS Registry Mumber 885524-81-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,5,2 and 4 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 885524-81:
(8*8)+(7*8)+(6*5)+(5*5)+(4*2)+(3*4)+(2*8)+(1*1)=212
212 % 10 = 2
So 885524-81-2 is a valid CAS Registry Number.
885524-81-2Relevant articles and documents
DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS
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Paragraph 0388, (2013/05/08)
Compounds, pyridine N-oxides, and pharmaceutically acceptable salts of formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and for preventing and/ or treating diseases of the respiratory tract characterized by airway obstruction, such as asthma or COPD.
Virtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitors
Zou, Yiquan,Li, Li,Chen, Wuyan,Chen, Tiantian,Ma, Lanping,Wang, Xin,Xiong, Bing,Xu, Yechun,Shen, Jingkang
, p. 5706 - 5722 (2013/06/27)
Proteolytic cleavage of amyloid precursor protein by β-secretase (BACE1) is a key step in generating the N-terminal of β-amyloid (Aβ), which further forms into amyloid plaques that are considered as the hallmark of Alzheimer's disease. Inhibitors of BACE1 can reduce the levels of Aβ and thus have a therapeutic potential for treating the disease. We report here the identification of a series of small molecules bearing an indole acylguanidine core structure as potent BACE1 inhibitors. The initial weak fragment was discovered by virtual screening, and followed with a hit-to-lead optimization. With the aid of co-crystal structures of two discovered inhibitors (compounds 19 and 25) with BACE1, we explored the SAR around the indole and aryl groups, and obtained several BACE1 inhibitors about 1,000-fold more potent than the initial fragment hit. Accompanying the lead optimization, a previously under-explored sub-site opposite the flap loop was redefined as a potential binding site for later BACE1 inhibitor design.
