885590-99-8

Basic information

• Product Name: 2,3-DIFLUORO-4-IODOBENZALDEHYDE
• Synonyms: 2,3-DIFLUORO-4-IODOBENZALDEHYDE
• CAS NO: 885590-99-8
• Molecular Formula: C₇H₃F₂IO
• Molecular Weight: 267.9993964
• Product Categories: Liquid Crystal intermediates
• Mol File: 885590-99-8.mol

Chemical Properties

• Boiling Point: 261.7°C at 760 mmHg
• Flash Point: 112.1°C
• Appearance: /
• Density: 2.036g/cm³
• Vapor Pressure: 0.0113mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2,3-DIFLUORO-4-IODOBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIFLUORO-4-IODOBENZALDEHYDE(885590-99-8)
• EPA Substance Registry System: 2,3-DIFLUORO-4-IODOBENZALDEHYDE(885590-99-8)

Safety Data

• Hazardous Substances Data: 885590-99-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2,3-Difluoro-4-iodobenzaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Production:
This chemical compound is also used as an intermediate in the production of agrochemicals, contributing to the development of more effective and targeted pesticides and other agricultural chemicals.
Used in Electronic Materials Manufacturing:
2,3-Difluoro-4-iodobenzaldehyde is utilized in the manufacture of electronic materials, where its unique properties can enhance the performance of various electronic devices and components.
Used as a Reagent in Organic Synthesis:
Due to its reactivity, 2,3-difluoro-4-iodobenzaldehyde serves as a reagent in the preparation of other fluorinated aromatic compounds, facilitating the synthesis of a wide range of organic molecules for various applications across different industries.

InChI:InChI=1/C7H3F2IO/c8-6-4(3-11)1-2-5(10)7(6)9/h1-3H

Upstream product

• 885590-98-7 2-(2,3-difluoro-4-iodophenyl)[1,3]dioxolane 

Downstream Products

• 885591-00-4 (2,3-difluoro-4-iodo-phenyl)-trimethylsilanyloxy-acetonitrile 

Relevant articles and documents

7-Fluoroindazoles as potent and selective inhibitors of factor Xa

We have developed a novel series of potent and selective factor Xa inhibitors that employ a key 7-fluoroindazolyl moiety. The 7-fluoro group on the indazole scaffold replaces the carbonyl group of an amide that is found in previously reported factor Xa inhibitors. The structure of a factor Xa cocrystal containing 7-fluoroindazole 51a showed the 7-fluoro atom hydrogen-bonding with the N-H of Gly216 (2.9 ?) in the peptide backbone. Thus, the 7-fluoroindazolyl moiety not only occupied the same space as the carbonyl group of an amide found in prior factor Xa inhibitors but also maintained a hydrogen bond interaction with the protein's β-sheet domain. The structure-activity relationship for this series was consistent with this finding, as the factor Xa inhibitory potencies were about 60-fold greater (ΔΔG ≈ 2.4 kcal/mol) for the 7-fluoroindazoles 25a and 25c versus the corresponding indazoles 25b and 25d. Highly convergent synthesis of these factor Xa inhibitors is also described.

FACTOR XA COMPOUNDS

The present invention is directed to novel compounds of Formula (I) and forms and pharmaceutical compositions thereof, and the use thereof as inhibitors of Factor Xa.