885698-95-3

Usage

Uses

Used in Organic Synthesis:
2-Methyl-2H-indazole-4-boronic acid pinacol ester is used as a reagent for the formation of carbon-carbon and carbon-heteroatom bonds, facilitating the synthesis of complex organic molecules.
Used in Suzuki-Miyaura Coupling Reactions:
In the field of cross-coupling reactions, 2-Methyl-2H-indazole-4-boronic acid pinacol ester is used as a boronic acid component to form biaryl compounds, which are crucial in the creation of pharmaceuticals and materials with specific electronic and steric properties.
Used as a Protecting Group in Organic Synthesis:
The pinacol ester functional group in 2-Methyl-2H-indazole-4-boronic acid pinacol ester serves as a protecting group for alcohols, which is essential in organic synthesis to prevent unwanted reactions at the alcohol functional group.
Used in the Development of Pharmaceuticals:
2-Methyl-2H-indazole-4-boronic acid pinacol ester is utilized as a building block in the synthesis of pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications.
Used in the Synthesis of Agrochemicals:
2-Methyl-2H-indazole-4-boronic acid pinacol ester is also employed in the agrochemical industry, where it is used in the synthesis of various agrochemicals, including pesticides and herbicides, to improve crop protection and yield.

InChI:InChI=1/C14H19BN2O2/c1-13(2)14(3,4)19-15(18-13)11-7-6-8-12-10(11)9-17(5)16-12/h6-9H,1-5H3

Upstream product

• 186407-74-9 4-bromoindazole 
• 590417-93-9 4-bromo-2-methylindazole 
• 73183-34-3 bis(pinacol)diborane 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

METHODS OF TREATING LIVER FIBROSIS USING CALPAIN INHIBITORS

Disclosed herein are methods of treating liver fibrosis by administering calpain inhibitors to subjects in need thereof.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Small molecule calpain modulator compounds, including their pharmaceutically acceptable salts, can be included in pharmaceutical compositions. The compounds can be useful in inhibiting calpain, or competitive binding with calpastatin, by contacting them with CAPN1, CAPN2, and/or CAPN9 enzymes residing inside a subject. The compounds and composition can also be administered to a subject in order to treat a fibrotic disease or a secondary disease state or condition of a fibrotic disease.

PHARMACEUTICAL COMPOUNDS

Fused pyrimidines of formula (I); wherein A represents a thiophene or furan ring; n is 1 or 2; R1 is a group of formula (II); wherein m is 0 or 1; R30 is H or C1-C6 alkyl; R4 and R5 form, together with the N atom to which they are attached, a 5- or 6-membered saturated N-containing heterocyclic group which includes 0 or 1 additional heteroatoms selected from N, S and O, which may be fused to a benzene ring and which is unsubstituted or substituted; or one of R4 and R5 is alkyl and the other is a 5- or 6-membered saturated N-containing heterocyclic group as defined above or an alkyl group which is substituted by a 5- or 6-membered saturated N-containing heterocyclic group as defined above; R2 is selected from formula (a); wherein R6 and R7 form, together with the nitrogen atom to which they are attached, a morpholine, thiomorpholine, piperidine, piperazine, oxazepane or thiazepane group which is unsubstituted or substituted; and formula (b); wherein Y is a C2-C4 alkylene chain which contains, between constituent carbon atoms of the chain and/or at one or both ends of the chain, 1 or 2 heteroatoms selected from O, N and S, and which is unsubstituted or substituted; and R3 is an indazole group which is unsubstituted or substituted; and the pharmaceutically acceptable salt thereof have activity as inhibitors of P13K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with P13 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.