885702-24-9Relevant academic research and scientific papers
Design, synthesis, and evaluation of a novel dual fms-like tyrosine kinase 3/stem cell factor receptor (FLT3/c-KIT) inhibitor for the treatment of acute myelogenous leukemia
Davies, Robert J.,Pierce, Albert C.,Forster, Cornelia,Grey, Ron,Xu, Jinwang,Arnost, Michael,Choquette, Deborah,Galullo, Vincent,Tian, Shi-Kai,Henkel, Greg,Chen, Guanjing,Heidary, David K.,Ma, Joanne,Stuver-Moody, Cameron,Namchuk, Mark
, p. 7184 - 7192 (2011/12/03)
A high-throughput screen of our compound archive revealed a novel class of dual FMS-like tyrosine kinase 3 (FLT3)/c-KIT inhibitors. With the help of molecular modeling, this class was rapidly optimized for both potency against FLT3 and FLT3/c-KIT and exce
TRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES
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Page/Page column 56-56, (2010/11/08)
The present invention relates to inhibitors of proteins kinases of formula (I). The invention also provides pharmaceuticals compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
