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Usage

Uses

Used in Cosmetics and Personal Care Industry:
1,4-Dihydroxy-3,3,6,6-tetramethylpiperazine-2,5-dione is used as a preservative in cosmetics and personal care products for its antimicrobial properties. It helps maintain product quality and safety by preventing the growth of harmful microorganisms, thus extending the shelf life and ensuring the efficacy of these products. However, due to potential allergic reactions and skin irritation, regulatory agencies have set limits on the concentration of DMDMH that can be used in these products.

InChI:InChI=1/C8H14N2O4/c1-7(2)5(11)10(14)8(3,4)6(12)9(7)13/h13-14H,1-4H3

Upstream product

• 88571-73-7 2,2,5,5-tetramethyl-2,5-dihydropyrazine 1,4-dioxide 

Relevant academic research and scientific papers

Preparation of 2,3- and 2,5-Dihydropyrazine 1,4-Dioxides from 2-Hydroxyamino-2-methylpropanal Oxime and Some of Their Properties

3-Hydroxy-2,3-dihydropyrazine 1,4-dioxide derivatives were obtained by condensation of 2-hydroxyamino-2-methylpropanal oxime with glyoxal, diacetyl, and 1,2-cyclohexanedione in water, and 3-methoxy-2,3-dihydropyrazine 1,4-dioxide was obtained by condensation with diacetyl in methanol. 2,5-Dihydropyrazine 1,4-dioxide is formed when 2-hydroxyamino-2-methylpropanal oxime is heated in a solution of acetone and dilute hydrochloric acid.The reduction of 3-hydroxy- and 3-methoxy-2,3-dihydropyrazine 1,4-dioxides and 2,5-dihydropyrazine 1,4-dioxide leads to 1,4-dihydroxypiperazines, and the bromination of 3-methoxy-2,3-dihydropyrazine 1,4-dioxide gives 5,6-bis(bromomethyl)-3-methoxy-2,3-dihydropyrazine 1,4-dioxide. 1,4-Dihydroxy-2,5-piperazinedione was obtained by oxidation of 2,5-dihydropyrazine 1,4-dioxide.