88576-94-7Relevant academic research and scientific papers
Time-dependence and preliminary SAR studies in inhibition of nitric oxide synthase isoforms by homologues of thiocitrulline
Goodyer, Claire L. M.,Chinje, Edwin C.,Jaffar, Mohammed,Stratford, Ian J.,Threadgill, Michael D.
, p. 3679 - 3680 (2003)
Treatment of Nα-Cbz-Nε -(2-hydroxyethylaminothiocarbonyl)-L-lysine N-(2-hydroxyethyl)amide with boiling hydrochloric acid gave Nε -(4,5-dihydrothiazol-2-yl)-L-lysine. This was a weak and non-isoform selective inhibitor of NOS, whereas Nε -aminothiocarbonyl-L-lysine and its methyl ester were potent, with IC 50=13 and 18 μM, respectively, against human iNOS and IC 50=3 and 8 μM, respectively, against rat nNOS. Time dependence was observed for inhibition of nNOS by the ester.
