88584-52-5

Upstream product

• 70135-28-3 (4-cyanophenyl)diazomethane 
• 105-07-7 4-cyanobenzaldehyde 
• 854630-96-9 4,4'-(2-oxa-propanediyl)-di-benzoic acid diamide 
• 617-86-7 triethylsilane 
• 1396318-76-5 bis(p-cyanobenzyl) sulfite 
• 874-89-5 4-Cyanobenzyl alcohol 
• 17201-43-3 4-cyanobenzyl bromide 
• 874-86-2 4-cyanobenzyl chloride 
• 55255-64-6 4,4'-[oxybis(methylene)]dibenzoic acid 

Downstream Products

• 4381-02-6 1,2-bis-(4-cyanophenyl)ethane 
• 874-89-5 4-Cyanobenzyl alcohol 
• 105-07-7 4-cyanobenzaldehyde 

Relevant academic research and scientific papers

Breaking C-O Bonds with Uranium: Uranyl Complexes as Selective Catalysts in the Hydrosilylation of Aldehydes

We report herein the possibility to perform the hydrosilylation of carbonyls using actinide complexes as catalysts. While complexes of the uranyl ion [UO2]2+ have been poorly considered in catalysis, we show the potentialities of the Lewis acid [UO2(OTf)2] (1) in the catalytic hydrosilylation of a series of aldehydes. [UO2(OTf)2] proved to be a very active catalyst affording distinct reduction products depending on the nature of the reductant. With Et3SiH, a number of aliphatic and aromatic aldehydes are reduced into symmetric ethers, while iPr3SiH yielded silylated alcohols. Studies of the reaction mechanism led to the isolation of aldehyde/uranyl complexes, [UO2(OTf)2(4-Me2N-PhCHO)3], [UO2(μ-κ2-OTf)2(PhCHO)]n, and [UO2(μ-κ2-OTf)(κ1-OTf)(PhCHO)2]2, which have been fully characterized by NMR, IR, and single-crystal X-ray diffraction.

Photolytic decomposition of dibenzylic sulfites

The photolytic decay of a library of para-substituted dibenzylic sulfites has been evaluated by UV radiation in a Srinivasan-Griffin-Rayonet photochemical reactor in various deuterated solvents. The decay for each dibenzylic sulfite was examined with respect to Swain and Lupton's field constant, F. The rate of photolytic decay varies depending on the identity of the benzyl substituents. Furthermore, it has been observed that the solvent affects both the rate of sulfite photolytic decay as well as final product distribution.

Copper(II) triflate-catalyzed reduction of carboxylic acids to alcohols and reductive etherification of carbonyl compounds

A protocol is described for the reduction of carboxylic acids to primary alcohols using 1,1,3,3-tetramethyldisiloxane (TMDS) and a catalytic amount of Cu(OTf)2. Aliphatic as well as aromatic carboxylic acids are reduced in high selectivity and good yields. TMDS/Cu(OTf)2 has also been found to be an efficient catalytic reducing system for the preparation of symmetrical ethers from carbonyl compounds under mild conditions.

Sulfonamide bridging compounds that inhibit tryptase activity

The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediated by mast cell activation. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds and methods for treating or preventing an inflammatory disease.

Reactivities of Carbonyl Compounds in Acid-Catalyzed Hydride Transfer vs. Electron Transfer

Rate constants for acid-catalyzed hydride-transfer reactions from triethylsilane to a series of carbonyl compounds are compared with those for acid-catalyzed electron transfer from the excited state of 2+ to the same series of carbonyl compounds in the presence of HClO4 in acetonitrile at 298 K.