885964-08-9

Basic information

• Product Name: 4-(2-Chloro-3-methylphenyl)benzoic acid
• Synonyms: 4-(2-Chloro-3-methylphenyl)benzoic acid;4-(2-Chloro-4-methylphenyl)benzoic acid;4-(2-Chloro-5-methylphenyl)benzoic acid;4-(2-Chloro-6-methylphenyl)benzoic acid;4-(3-Chloro-2+B231-methylphenyl)benzoic acid;4-(4-Fluoro-3-methylphenyl)benzoic acid;4-Fluoro-3-methyl-[1,1-biphenyl]-4-carboxylic acid
• CAS NO: 885964-08-9
• Molecular Formula: C14H11ClO2
• Molecular Weight: 230.23
• Mol File: 885964-08-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(2-Chloro-3-methylphenyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Chloro-3-methylphenyl)benzoic acid(885964-08-9)
• EPA Substance Registry System: 4-(2-Chloro-3-methylphenyl)benzoic acid(885964-08-9)

Safety Data

• Hazardous Substances Data: 885964-08-9(Hazardous Substances Data)

Usage

Structural Features

Contains a carboxylic acid group (-COOH)
Benzene ring with:
Chloro group (Cl) at the 2-position
Methyl group (CH3) at the 3-position

Applications

Pharmaceutical Industry:
Building block in drug synthesis
Used in the production of various pharmaceutical products
Organic Chemistry:
Reagent in chemical reactions
Intermediate in organic synthesis
Other Industries:
Potential applications in research and industrial processes

Versatility

Suitable for diverse applications due to its unique chemical structure
Offers flexibility in various chemical processes and reactions.

Upstream product

• 619-58-9 4-iodobenzoic acid 
• 139911-27-6 4-fluoro-3-methylphenyl boronic acid 
• 586-76-5 4-Bromobenzoic acid 

Relevant articles and documents

Perfluoro-tagged, phosphine-free palladium nanoparticles supported on silica gel: Application to alkynylation of aryl halides, Suzuki-Miyaura cross-coupling, and Heck reactions under aerobic conditions

The utilization of perfluoro-tagged palladium nanoparticles immobilized on fluorous silica gel through fluorous-fluorous interactions (Pd np-A/FSG) or through covalent bonding to silica gel (Pd np-B) in the alkynylation of aryl halides, in the Suzuki-Miyaura cross-coupling, as well as in the Heck reaction between methyl acrylate and aryl iodides is described. The reactions are carried out under aerobic and phosphine-free conditions with excellent to quantitative product yields in each case. The catalysts are easily recovered and reused several times without significant loss of activity. The alkynylation of aryl halides (under copper-free conditions) and the Suzuki-Miyaura cross-coupling are carried out in water. The Heck reaction of methyl acrylate with aryl iodides is best performed in MeCN. The utilization of Pdnp-B in the synthesis of 2,3-disubstituted indoles from 2-(alkynyl)trifluoroacetanilides and aryl halides is also reported.