886041-24-3Relevant academic research and scientific papers
Tetracyclic indole inhibitors of hepatitis C virus NS5B-polymerase
Stansfield, Ian,Ercolani, Caterina,Mackay, Angela,Conte, Immacolata,Pompei, Marco,Koch, Uwe,Gennari, Nadia,Giuliano, Claudio,Rowley, Michael,Narjes, Frank
scheme or table, p. 627 - 632 (2009/09/06)
We report the evolutionary path from an open-chain series to conformationally constrained tetracyclic indole inhibitors of HCV NS5B-polymerase, where the C2 aromatic is tethered to the indole nitrogen. SAR studies led to the discovery of zwitterionic comp
TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS
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Page/Page column 21-22, (2010/11/08)
The present invention relates to tetracyclic indole compounds of formula (I); wherein R1, R2, A, Ar, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
