886047-84-3Relevant academic research and scientific papers
Synthesis of indenes by the transition metal-mediated carboannulation of alkynes
Zhang, Daohua,Liu, Zhijian,Yum, Eul K.,Larock, Richard C.
, p. 251 - 262 (2007/10/03)
The synthesis of highly substituted indenes has been achieved by three different transition metal-mediated methods. The first method involves the palladium-catalyzed carboannulation of internal alkynes. The second method utilizes a two-step approach, which involves first the palladium/copper- catalyzed cross-coupling of terminal alkynes with appropriately functionalized aryl halides, followed by copper-catalyzed intramolecular cyclization. The third method involves intermolecular palladium-catalyzed arylation of the arylalkynes formed in the first step of the second method.
Synthesis of indenes via palladium-catalyzed carboannulation of diethyl 2-(2-(1-alkynyl)phenyl)malonate and organic halides
Guo, Li-Na,Duan, Xin-Hua,Bi, Hai-Peng,Liu, Xue-Yuan,Liang, Yong-Min
, p. 3325 - 3327 (2007/10/03)
Highly substituted indenes have been prepared in good yields by the palladium-catalyzed carboannulation of diethyl 2-(2-(1-alkynyl)phenyl)malonate with aryl, benzylic, and alkenyl halides. The reaction conditions and the scope of the process were examined, and a possible mechanism is proposed.
