88612-17-3Relevant academic research and scientific papers
η6-Arene CH?O Interaction Directed Dynamic Kinetic Resolution – Asymmetric Transfer Hydrogenation (DKR-ATH) of α-Keto/enol-Lactams
Chen, Yong,Lin, Yicao,Luo, Zhonghua,Sun, Guodong,Wang, Zhongqing,Wu, Shuming,Zhang, Lei
, p. 3030 - 3034 (2021)
A dynamic kinetic resolution – asymmetric transfer hydrogenation (DKR-ATH) methodology of α-keto/enol-lactams was developed. We also propose a possible catalytic mechanism evolving a transition state stabilized by η6-arene CH?O interaction. The efficient approach can be applied to a wide range of substrates including non-aryl ones which would be difficult to prepare by other asymmetric reduction methods. (Figure presented.).
Method for preparing lactam compound
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Paragraph 0074; 0078-0080, (2020/11/09)
The invention relates to a preparation method of a lactam compound, and belongs to the field of medicinal chemistry. The preparation method comprises the following steps: carrying out an asymmetric hydrogenation reaction on raw materials under the action of a ruthenium catalyst and a hydrogen donor reagent, and carrying out a post treatment to obtain the target compound. The product obtained by the method is high in ee value, the method is simple and convenient, and the target compound can be easily, conveniently and efficiently obtained.
β2, 2-Amino Acid N-Carboxyanhydrides Relying on Sequential Enantioselective C(4)-Functionalization of Pyrrolidin-2,3-diones and Regioselective Baeyer–Villiger Oxidation
Badiola, Eider,Olaizola, Iurre,Vázquez, Ana,Vera, Silvia,Mielgo, Antonia,Palomo, Claudio
supporting information, p. 8185 - 8195 (2017/06/23)
A catalytic enantioselective entry to β2, 2-amino acids enabling their direct coupling with nucleophiles is described. The approach is based upon an effective bifunctional Br?nsted base catalyzed construction of a quaternary carbon stereocenter at C4 position of pyrrolidin-2,3-diones. Subsequent regioselective Baeyer–Villiger oxidation of the resultant adducts gives β2, 2-amino acid N-carboxyanhydrides as the reactive species, which can further react with nucleophiles. Following this strategy both, β2, 2-amino acid derivatives with different functionalities at the newly created stereocenter, and spirocyclic structures can be efficiently prepared.
