88614-99-7

Basic information

• Product Name: N-(4-(N-(3-methylisoxazol-5-yl)sulfamoyl)phenyl)acetamide
• CAS NO: 88614-99-7
• Molecular Weight: 295.319
• Mol File: 88614-99-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-(N-(3-methylisoxazol-5-yl)sulfamoyl)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(N-(3-methylisoxazol-5-yl)sulfamoyl)phenyl)acetamide(88614-99-7)
• EPA Substance Registry System: N-(4-(N-(3-methylisoxazol-5-yl)sulfamoyl)phenyl)acetamide(88614-99-7)

Safety Data

• Hazardous Substances Data: 88614-99-7(Hazardous Substances Data)

Upstream product

• 14678-02-5 5-amino-3-methylisoxazole 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 

Downstream Products

• 17103-52-5 4-amino-N-(3-methyl-1,2-oxazol-5-yl)benzene-1-sulfonamide 

Relevant articles and documents

Facile and convenient synthesis of new isoxazolo[5,4b]pyridine, pyrrolo[3,2-d]isoxazole, isoxazolo[5,4-b]azepine-4,7-dione and isoxazole derivatives with potential anticancer activity

The readily available 3-methylisoxazol-5-amine (1) has been used as a key intermediate for the synthesis of isoxazolo[5,4-b]pyridine, pyrrolo[3,2-d]isoxazole, isoxazolo[5,4-b]azepine-4,7-dione and isoxazole derivatives via its reactions with some chemical reagents. Sixteen compounds were designed to study their cytotoxic properties against three human cell lines: colorectal carcinoma (HCT-116), prostate cancer (PC3) and normal lung fibroblast (WI-38), using the MTT colorimetric assay. 5-Fluorouracil, a well-known anticancer drug, was used for comparison. Among the tested candidates, pyrrolo[3,2-d]isoxazole 5 and isoxazole derivatives 11-14 showed the highest activity against the tested cancer cell lines with good selectivity by their lower toxicity against normal cells.