88621-01-6

Basic information

• Product Name: CefixiMe Methyl Ester
• Synonyms: CefixiMe Methyl Ester
• CAS NO: 88621-01-6
• Molecular Formula: C₁₇H₁₇N₅O₇S₂
• Molecular Weight: 467.47618
• Product Categories: Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 88621-01-6.mol

Chemical Properties

• Appearance: /
• Density: 1.73±0.1 g/cm3(Predicted)
• Solubility: Methanol
• PKA: 2.79±0.50(Predicted)
• CAS DataBase Reference: CefixiMe Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: CefixiMe Methyl Ester(88621-01-6)
• EPA Substance Registry System: CefixiMe Methyl Ester(88621-01-6)

Safety Data

• Hazardous Substances Data: 88621-01-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Cefixime Methyl Ester is used as an intermediate in the synthesis of Cefixime (C242800) for its development and production. This antibiotic is effective against a wide range of bacterial infections, making it a valuable component in the pharmaceutical industry.

Upstream product

• 80544-17-8 2-(2-aminothiazol-4-yl)-2-[(Z)-methoxycarbonylmethoxyimino]acetic acid 
• 79349-82-9 (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 17356-08-0 thiourea 

Downstream Products

• 79350-37-1 cefixime 

Relevant articles and documents

Method of synthesizing cefixime

The invention discloses a method for synthesizing cefixime. The method comprises the following steps: (1) carrying out an amidation reaction between MICA ((Z)-2-(methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid) sulfur-phosphorous active ester and 7-AVCA to obtain cefixime methyl ester, wherein the structure of the MICA sulfur-phosphorous active ester is as shown in the formula (II); (2) hydrolyzing the cefixime methyl ester to obtain cefixime. According to the synthesizing method, a new MICA active ester, namely (z)-2-(2-amino-4-thiazolyl)-methoxycarbonyl methylene imino-acetic acid-diethyl phosphoryl active ester, is adopted, a byproduct diethyl phosphate has small toxicity; and the diethyl phosphate is liquid and can be easily removed, the method is simple in steps and is high in yield.

PROCESS FOR THE PREPARATION OF CEFIXIME

The present invention provides an improved process for the preparation of Cefixime of formula (I), a cephalosporine antibiotic with an improved quality in regard to color and solubility.

Process for purification of a cephalosporin derivative

A process for the purification of cefixime via a novel tert.octylamine salt of a cefixime intermediate which may be crystalline and which may be produced in a one pot reaction from 7-amino-3-vinyl-ceph-3-em-4-carboxylic acid.