886221-74-5

Basic information

• Product Name: 3-fluoro-1-aminopyridinium mesitylenesulfonate
• Synonyms: 3-fluoro-1-aminopyridinium mesitylenesulfonate
• CAS NO: 886221-74-5
• Molecular Weight: 312.365
• Mol File: 886221-74-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-fluoro-1-aminopyridinium mesitylenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-1-aminopyridinium mesitylenesulfonate(886221-74-5)
• EPA Substance Registry System: 3-fluoro-1-aminopyridinium mesitylenesulfonate(886221-74-5)

Safety Data

• Hazardous Substances Data: 886221-74-5(Hazardous Substances Data)

Upstream product

• 372-47-4 3-Fluoropyridine 
• 36016-40-7 mesitylenesulfonylhydroxylamine 
• 38202-27-6 ethyl O-(2-mesitylenesulfonyl)acetohydroxamate 
• 36016-39-4 N-(tert-butoxycarbonyl)-O-(mesitylsulfonyl)hydroxylamine 

Relevant articles and documents

Regioselective Synthesis of Pyrazolo[1,5- a]pyridine via TEMPO-Mediated [3 + 2] Annulation-Aromatization of N-Aminopyridines and α,β-Unsaturated Compounds

A TEMPO-mediated [3 + 2] annulation-aromatization protocol for the preparation of pyrazolo[1,5-a]pyridines from N-aminopyridines and α,β-unsaturated compounds was developed. The procedure offered multisubstituted pyrazolo[1,5-a]pyridines in good to excellent yield with high and predictable regioselectivity. The modification of marketed drugs including Loratadine, Abiraterone, and Metochalcone, and a one-pot three-step gram scale synthesis of key intermediate for the preparation of Selpercatinib were demonstrated. Mechanism studies show that TEMPO serves both as a Lewis acid and as an oxidant.

HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS

New heteroaryl imidazolone derivatives having the chemical structure of formula (I) disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

Pyrazolopyridine-4-Yl Pyridazinone Derivatives and Addition Salts Thereof, and Pde Inhibitors Comprising the Same Derivatives or Salts as Active Ingredient

Novel pyrazolopyridine-4-yl pyridazinone derivatives serve as phosphodiesterase inhibitors and are useful compounds for use in pharmaceutical products. Specifically, the compounds of the present invention are pyrazolopyridine-4-yl pyridazinone derivatives represented by the following general formula (1): (Example: 6-(2-ethyl-7-methoxy-pyrazolo[1,5-a]pyridine-4-yl)-5-methyl-4, 5-dihydro-3(2H)-pyridazinone).