886230-77-9 Usage
Uses
(E)-6-Iodo-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole is an intermediate used to prepare Axitinib (A794650) as a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
Synthesis
6-amino-3-((E)-2-pyridin-2-yl-vinyl)-1-(tetrahydropyran-2-yl)-1 H-indazole (100 g) dissolved in
acetic acid (6.5 L) is added over 1.5 hours to a solution of sodium nitrite (35 g) dissolved in
water (3.0 L) at 0℃ (-3 ± 3°C). The mixture is stirred for 1 hour at 0℃, and a solution of
hydrochloric acid (560 mL diluted in 1 L of water) at 0℃ is added over 15 minutes. The mixture
is stirred for 1 hour at 0℃. The formation of the diazonium salt is monitored by HPLC.
Dicholoromethane (400 ml) at O0C is added over 10 minutes to the diazonium salt solution at
0℃, and a solution of potassium iodide (207. 25 g) dissolved in water (300 ml) at O0C is added
over 1.5 hours. The reaction mixture is agitated for 3 hours at 0℃ (until complete by HPLC).
The mixture is then poured into a solution of sodium bisulfite in process water [Sodium bisulfite
(200g) dissolve in process water (500mL) at 27± 3°C] and Dicholoromethane (400 ml) below
270C, agitated, and the layers separated. The aqueous layer is extracted with Dichloromethane (100 ml) at 27℃ and combined. A solution of aqueous ammonia (100 ml) at 27± 3°C is added
over 40 minutes to the combined organic layers until the aqueous phase is basic (pH = 9 to 12).
Distill out dichloromethane and add methanol and heat to 50 ± 3°C and stir it at this temperature
for 15 min and then stir for 30 min at RT, followed by washing with methanol. Add
dichloromethane and heat to 45± 3°C and add activated carbon at this temperature. Followed by
addition of methanol and dichloromethane (if required) and stir the reaction mixture at 27± 3°C
for 30 min and cool it to 0±3°C and stir 1 hr and wash with methanol to provide (E)-6-Iodo-3-[2-
(pyridine-2yl)ethenyl]-1 -(tetrahydro-2H- pyran-2-yl)-1H-indazole.
Check Digit Verification of cas no
The CAS Registry Mumber 886230-77-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,2,3 and 0 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 886230-77:
(8*8)+(7*8)+(6*6)+(5*2)+(4*3)+(3*0)+(2*7)+(1*7)=199
199 % 10 = 9
So 886230-77-9 is a valid CAS Registry Number.
