88625-24-5

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloropyrazine-2-carbaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical properties allow it to be a versatile component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Chloropyrazine-2-carbaldehyde is utilized as a precursor in the production of agrochemicals. Its role in creating effective and targeted compounds makes it an essential part of developing solutions for agricultural challenges.
Used in Dye and Pigment Production:
5-Chloropyrazine-2-carbaldehyde is used as an intermediate in the manufacturing of dyes and pigments. Its ability to undergo different chemical reactions enables the creation of a wide range of colorants for various applications, including textiles, plastics, and printing inks.
Used in Organic Chemistry Research:
As a versatile building block, 5-Chloropyrazine-2-carbaldehyde is also used in organic chemistry research for exploring new reaction pathways and developing innovative synthetic methods. Its reactivity and stability make it a valuable tool for scientists in the field of organic chemistry.

Upstream product

• 72788-94-4 (5-chloro-2-pyrazinyl)methanol 
• 36070-80-1 5-chloropyrazinoic acid 
• 33332-25-1 methyl 5-chloropyrazine-2-carboxylate 

Downstream Products

• 72788-94-4 (5-chloro-2-pyrazinyl)methanol 

Relevant academic research and scientific papers

SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

N-(2-(4-((1R,3R)-3-METHYL-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOL-1-YL)PHENOXY)ETHYL)PROPAN-1-AMINE DERIVATIVES AND RELATED COMPOUNDS AS SELECTIVE DOWN-REGULATORS OF THE ESTROGEN RECEPTOR FOR TREATING CANCER

The specification relates to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, pharmaceutical compositions containing them and to the compounds of Formula (I) for use as selective down-regulators of the estrogen receptor in the treatment of cell proliferative disorders, such as cancer.

Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

A series of 6-hetaryloxy benzoxaborole compounds was designed and synthesized for a structure-activity relationship (SAR) investigation to assess the changes in antimalarial activity which result from 6-aryloxy structural variation, substituent modification on the pyrazine ring, and optimization of the side chain ester group. This SAR study discovered highly potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles (9, 27-34) with IC50s = 0.2-22 nM against cultured Plasmodium falciparum W2 and 3D7 strains. Compound 9 also demonstrated excellent in vivo efficacy against P. berghei in infected mice (ED90 = 7.0 mg/kg).

CONTINUOUS ARYCYCLIC COMPOUND

This is to provide a continuous arycyclic compound having a DGAT1 inhibitory activity, and useful for prophylaxis and/or treatment of obesity or hyperlipidemia caused by obesity, hypertriglyceridemia, lipid metabolism disorder, fatty liver, hypertension,