88628-64-2

Basic information

• Product Name: (1S,2R)-2-Amino-5-benzyloxy-indan-1-ol; hydrochloride
• Synonyms: (1S,2R)-2-Amino-5-benzyloxy-indan-1-ol; hydrochloride
• CAS NO: 88628-64-2
• Molecular Weight: 291.777
• Mol File: 88628-64-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2R)-2-Amino-5-benzyloxy-indan-1-ol; hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R)-2-Amino-5-benzyloxy-indan-1-ol; hydrochloride(88628-64-2)
• EPA Substance Registry System: (1S,2R)-2-Amino-5-benzyloxy-indan-1-ol; hydrochloride(88628-64-2)

Safety Data

• Hazardous Substances Data: 88628-64-2(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 5111-70-6 5-methoxy-1-indanone 
• 3470-49-3 5-hydroxy-2,3-dihydro-1H-indene-1-one 
• 78326-88-2 5-benzyloxy-1-indanone 
• 88628-63-1 5-Benzyloxy-indan-1,2-dione 2-oxime 

Downstream Products

• 88628-02-8 (1S,2R)-5-Benzyloxy-2-isopropylamino-indan-1-ol; hydrochloride 
• 88627-99-0 cis-5-hydroxy-2-(1-methyl-3-phenylpropyl)aminoindan-1-ol 
• 88628-01-7 (1S,2R)-5-Benzyloxy-2-(1-methyl-3-phenyl-propylamino)-indan-1-ol; compound with (E)-but-2-enedioic acid 

Relevant articles and documents

Synthesis of 2-(N-substituted amino)-6-hydroxy-1,2,3,4-tetrahydronaphthalen-1-ol derivatives

trans-6-Hydroxy-2-(1-methyl-3-phenylpropyl)amino-1,2,3,4-tetrahydronaphth alen-1-ol (8a), trans-6-hydroxy-2-(1-methyl-2-phenoxyethyl)amino-1,2,3,4-tetrahydronaphtha len-1-ol (8b) and trans-1,6-dihydroxy-2-(1-methyl-3-phenylpropyl)amino-1,2,3,4-tetrahydronap hthalene-5-carboxamide (9a) were synthesized as a part of our search for useful cardiovascular agents. 2-(N-Substituted amino)-6-alkoxy-1,2,3,4-tetrahydronaphthalen-1-ols (10-31) having various substituents at the 5-, 6- and 7-positions of the naphthalene ring were prepared by a five-step sequence of reactions starting from 3,4-dihydro-1(2H)-naphthalenone derivatives (36). Furthermore 2-(N-substituted amino)-1-indanol derivatives (33) and 6-(N-substituted amino)-2-hydroxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ols (34, 35) were obtained by the reductive alkylation of the corresponding amino alcohols with carbonyl compounds. These N-substituted amino alcohols (8-35) were tested for vasodilating activity in anesthetized dogs and for β-blocking activity using isolated guinea pig atrial preparations.