886362-27-2 Usage
Uses
Used in Organic Synthesis:
8-N-BOC-AMINO-1,4-DIOXA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID is used as a building block in organic synthesis for its unique structure and functional groups. The BOC-protected amino group allows for selective reactions, while the spirocyclic ring system and carboxylic acid group provide additional points of reactivity and opportunities for further functionalization.
Used in Drug Development:
8-N-BOC-AMINO-1,4-DIOXA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID is used as a potential lead compound in drug development due to its unique structure and functional groups. The BOC protecting group can be selectively removed to reveal the free amino group, enabling the formation of amide bonds and other reactions that are crucial for the synthesis of bioactive molecules. The spirocyclic ring system and carboxylic acid group may also contribute to the compound's biological activity and pharmacokinetic properties, making it a promising candidate for further optimization and development as a therapeutic agent.
Used in Pharmaceutical Industry:
8-N-BOC-AMINO-1,4-DIOXA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID is used as an intermediate in the synthesis of pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for the development of new drugs with novel mechanisms of action and improved pharmacological properties.
Used in Chemical Research:
8-N-BOC-AMINO-1,4-DIOXA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID is used as a research tool in chemical studies to explore the reactivity and properties of its unique structure. 8-N-BOC-AMINO-1,4-DIOXA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID can be employed in various chemical reactions to investigate its potential as a precursor for the synthesis of complex organic molecules and to understand the effects of its structural features on reaction outcomes and product formation.
Check Digit Verification of cas no
The CAS Registry Mumber 886362-27-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,3,6 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 886362-27:
(8*8)+(7*8)+(6*6)+(5*3)+(4*6)+(3*2)+(2*2)+(1*7)=212
212 % 10 = 2
So 886362-27-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H23NO6/c1-12(2,3)21-11(18)15-13(10(16)17)4-6-14(7-5-13)19-8-9-20-14/h4-9H2,1-3H3,(H,15,18)(H,16,17)
886362-27-2Relevant academic research and scientific papers
Pettersson, Mariell,Quant, Maria,Min, Jaeki,Iconaru, Luigi,Kriwacki, Richard W.,Waddell, M. Brett,Guy, R. Kiplin,Luthman, Kristina,Grotli, Morten
, (2015)
The transcription factor p53 is the main tumour suppressor in cells and many cancer types have p53 mutations resulting in a loss of its function. In tumours that retain wild-type p53 function, p53 activity is down-regulated by MDM2 (human murine double minute 2) via a direct protein-protein interaction. We have designed and synthesised two series of 2,5-diketopiperazines as inhibitors of the MDM2-p53 interaction. The first set was designed to directly mimic the α-helical region of the p53 peptide, containing key residues in the i, i+4 and i+7 positions of a natural α-helix. Conformational analysis indicated that 1,3,6-trisubstituted 2,5-diketopiperazines were able to place substituents in the same spatial orientation as an α-helix template. The key step of the synthesis involved the cyclisation of substituted dipeptides. The other set of tetrasubstituted 2,5-diketopiperazines were designed based on structure-based docking studies and the Ugi multicomponent reaction was used for the synthesis. This latter set comprised the most potent inhibitors which displayed micromolar IC50-values in a biochemical fluorescence polarisation assay.
