886364-74-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(5-Methoxypyridin-3-yl)ethanone is used as an intermediate for the synthesis of various drugs, contributing to the development of new pharmaceuticals with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(5-Methoxypyridin-3-yl)ethanone is employed as an intermediate in the production of pesticides, aiding in the creation of effective solutions for pest control and crop protection.
Used in Research and Development:
1-(5-Methoxypyridin-3-yl)ethanone is utilized as a building block in research and development, enabling the design and synthesis of new chemical compounds with potential applications in various fields.
Used in Organic Chemistry:
As a versatile reagent in organic chemistry, 1-(5-Methoxypyridin-3-yl)ethanone is employed in various chemical reactions and processes, contributing to the advancement of organic synthesis and the discovery of novel compounds.

Upstream product

• 50720-12-2 3-bromo-5-methoxypyridine 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 113118-83-5 5-methoxypyridine-3-carboxaldehyde 
• 35307-06-3 1-(5-methoxypyridin-3-yl)ethanol 
• 625-92-3 3,5-dibromopyridine 

Relevant academic research and scientific papers

NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF

There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other, and each of R1 and R2 represents a hydrogen atom or the like; R3, R4, and R5 are the same as or different from each other, and each of R3, R4, and R5 represents a hydrogen atom, NRaRb, or the like; and each of Ra and Rb represents a hydrogen atom, a C1-8 alkyl group which may have a substituent, or the like.)

BCR-ABL TYROSINE-KINASE LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME

Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. invivo) to form a multimer (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding sites on a Bcr-Abl tyrosine kinase.

COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to beat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFRα and PDGFRβ kinases. Formula (I).

COMPOUNDS AND COMPOSITIONS AS C-KIT AND PDGFR KINASE INHIBITORS

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFR and PDGFR kinases.

Palladium-catalyzed regiocontrolled internal heteroarylation of electron-rich olefins with heteroaryl halides

A highly efficient palladium-catalyzed Heck coupling reaction of heteroaryl halides with electron-rich vinyl ether and hydroxyalkyl vinyl ethers is described. It was found that the choice of solvent, ligand, and reaction temperature had a fundamental influence on the regioselectivity and reactivity of the reaction, and the combination of Pd(OAc)2 and DPPF in ethylene glycol led to the most effective catalytic system. Under these conditions, a variety of heteroaryl halides reacted very quickly with electron-rich olefins to afford exclusively the branched products in good to excellent yields without employing triflates, halide scavengers, or ionic liquids.