886367-24-4

Basic information

• Product Name: 7,9-DIMETHYL-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE
• Synonyms: 7,9-DIMETHYL-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE;7,9-dimethyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
• CAS NO: 886367-24-4
• Molecular Formula: C12H15NO
• Molecular Weight: 189.2536
• Mol File: 886367-24-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7,9-DIMETHYL-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7,9-DIMETHYL-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE(886367-24-4)
• EPA Substance Registry System: 7,9-DIMETHYL-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE(886367-24-4)

Safety Data

• Hazardous Substances Data: 886367-24-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7,9-DIMETHYL-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE is used as a pharmaceutical compound for its potential therapeutic applications. Its unique structure may allow it to interact with biological targets, such as receptors or enzymes, and modulate their activity. This could lead to the development of new drugs for treating various diseases and conditions.
Used in Material Science:
In the field of material science, 7,9-DIMETHYL-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE may be utilized for its specific properties, such as stability, reactivity, or binding affinity. It could be incorporated into the development of new materials with tailored characteristics, such as sensors, catalysts, or advanced materials for various applications.

Upstream product

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Relevant articles and documents

A method of preparing intermediates (Evacetrapib) according to fills Qu Pi

The invention belongs to the field of drug synthesis, and particularly relates to a method for synthesizing an important intermediate 7, 9-dimethyl-2, 3, 4, 5-tetrahydro-1H-1-benzo-azepine-5-one of cholesteryl ester transfer protein (CETP) inhibitor evace

Synthesis of Methyl 7,9-Dimethyl-5-oxo-2,3,4,5-tetrahydro-1 H -benzo[ b ]azepine-1-carboxylate and Its Analogues

A high-yielding five-step synthesis of the title compound, methyl 7,9-dimethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate, starting from 2,4-dimethylaniline was developed. This synthesis involved N-alkylation of 2,4-dimethylaniline with ethyl 4-bromobutyrate to obtain ethyl 4-[(2,4-dimethylphenyl)amino]butanoate. Carbamoylation of the latter followed by hydrolysis of the resulting ester provided 4-[(2,4-dimethylphenyl) (methoxycarbonyl)amino]butanoic acid. Activation of the carboxylic acid using thionyl chloride followed by intramolecular cyclization via a Friedel-Crafts reaction using aluminum trichloride provided the title compound in good yield. Analogues of the title compound were also prepared similarly. Georg Thieme Verlag Stuttgart New York.