88639-72-9Relevant articles and documents
Anticoagulant 3-aralkyl-4-hydroxy-2-pyrones
Rehse,Schinkel
, p. 988 - 994 (2007/10/02)
Nine title compounds were synthesized and tested for their anticoagulant activity. After oral administration of a single dose of 330 mg/kg to rats, prothrombin levels below 15% were seen with 6 compounds. With two compounds the same result was obtained when the dose was reduced to 165 mg/kg. With the most active compound, the maximum effect was reached after 12 h and maintained up to 48 h. The existence of tautomeric 2-hydroxy-4-pyrones is discussed.