886451-53-2Relevant academic research and scientific papers
Synthesis, characterization and in vitro cytotoxicity of Co(II) complexes with N6-substituted adenine derivatives: X-ray structures of 6-(4-chlorobenzylamino)purin-di-ium diperchlorate dihydrate and [Co 6(μ-L6)4Cl8(DMSO)10] ? 4DMSO
Klanicová, Alena,Trávní?ek, Zdeněk,Popa, Igor,?ajan, Michal,Dole?al, Karel
, p. 1421 - 1432 (2008/10/09)
Cobalt(II) complexes of the composition [Co(L1)Cl(H 2O)2] ? H2O (1), [Co(L2) Cl(H2O)2] ? 2H2O (2), [Co(L 3)Cl(H2O)2] ? H2O (3), [Co(L4)Cl(H2O)2] ? H2O (4), [Co(L5)Cl(H2O)2] ? H2O (5) and [Co(L6)Cl(H2O)2] ? H2O (6), where HL1 = 6-(3-chlorobenzylamino)purine, HL2 = 6-(4-chlorobenzylamino)purine, HL3 = 6-(2,3-dimethoxybenzylamino) purine, HL4 = 6-(3,4-dimethoxybenzylamino)purine, HL5 = 6-(3-fluorobenzylamino)purine and HL6 = 6-(4-fluorobenzylamino) purine, have been prepared. The compounds have been characterized by elemental analyses, ES+ mass, UV-Vis, IR and NMR spectroscopies, magnetic measurements, molar conductances and thermogravimetric analysis as mononuclear tetrahedral high-spin cobalt(II) complexes. In vitro cytotoxicities of the complexes were tested by a Calcein AM assay against the following human tumour cell lines: malignant melanoma (G361), chronic myelogenous erythroleukemia (K562), osteogenic sarcoma (HOS) and breast adenocarcinoma (MCF7). The molecular structures of 6-(4-chlorobenzylamino)purin-di-ium diperchlorate dihydrate, [H2+L2](ClO4)2 ? 2H 2O, and a hexanuclear Co(II) complex, [Co6(μ-L 6)4Cl8(DMSO)10] ? 4DMSO (7), have been determined by a single crystal X-ray analysis. To elucidate the manner of the organic ligand coordination to cobalt, the geometry of the complex 2 was optimized using DFT calculations at the B3LYP/6-311+G* level of the theory.
