88649-03-0Relevant articles and documents
SYNTHESIS OF 2-HYDROXYMETHYLENE- AND 2-DIMETHYLAMINOMETHYLENE-3-OXOQUINUCLIDINES AND THEIR REACTIONS WITH NUCLEOPHILIC REAGENTS
Gorbyleva, O. I.,Filipenko, T. Ya.,Mikhlina, E. E.,Turchin, K. F.,Sheinker, Yu. N.,Yakhontov, L. N.
, p. 948 - 954 (1982)
The reaction of 3-oxoquinuclidine with ethyl formate in the presence of sodium and with dimethylformamide diethylacetal was used to synthesize 2-hydroxymethylene- and 2-dimethylaminomethylene-3-oxoquinuclidines, which upon reaction with amines from N-substituted 2-aminomethylene-3-oxoquinuclidines and upon reaction with hydrazine hydrate give pyrazoloquinuclidines.The reaction of 2-aryl- and 2-heteroarylmethylene-3-oxoquinuclidines with hydrazine hydrate and thiourea, which led to the synthesis of pyrazolo- and pyrimidoquinuclidines with aryl or heteroaryl substituents in the resulting ring, was studied.