886496-67-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(TRIFLUOROMETHYL)BENZENE-1-CARBOTHIOAMIDE is used as a chemical intermediate for the synthesis of various medicinal compounds. Its unique combination of functional groups makes it a valuable building block in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Chemical Industry:
2-(TRIFLUOROMETHYL)BENZENE-1-CARBOTHIOAMIDE is used as a reagent in organic synthesis processes. Its reactivity, particularly from the trifluoromethyl group, allows for the creation of a wide range of chemical products, from specialty chemicals to advanced materials.
Used in Research and Development:
2-(TRIFLUOROMETHYL)BENZENE-1-CARBOTHIOAMIDE is employed as a research compound in academic and industrial laboratories. Its properties and reactivity are studied to understand its potential applications and to develop new synthetic methods or improve existing ones.

InChI:InChI=1/C8H6F3NS/c9-8(10,11)6-4-2-1-3-5(6)7(12)13/h1-4H,(H2,12,13)

Upstream product

• 447-60-9 2-(trifluoromethyl)benzonitrile 

Downstream Products

• 929693-64-1 ethyl 4-methyl-2-[2-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate 
• 1334212-41-7 3,5-bis(2-(trifluoromethyl)phenyl)-1,2,4-thiadiazole 
• 1415718-76-1 C₁₆H₁₀F₃NS 
• 929693-74-3 ethyl 2-methyl-2-[(4-{[({4-methyl-2-[2-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenyl)oxy]propanoate 
• 929693-65-2 4-methyl-2-[2-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid 

Relevant academic research and scientific papers

Optimization, Structure-Activity Relationship, and Mode of Action of Nortopsentin Analogues Containing Thiazole and Oxazole Moieties

Plant diseases seriously endanger plant health, and it is very difficult to control them. A series of nortopsentin analogues were designed, synthesized, and evaluated for their antiviral activities and fungicidal activities. Most of these compounds displayed higher antiviral activities than ribavirin. Compounds 1d, 1e, and 12a, with excellent antiviral activities, emerged as novel antiviral lead compounds, among which 1e was selected for further antiviral mechanism research. The mechanism research results indicated that these compounds may play an antiviral role by aggregating viral particles to prevent their movement in plants. Further fungicidal activity tests revealed that nortopsentin analogues displayed broad-spectrum fungicidal activities. Compounds 2p and 2f displayed higher antifungal activities against Alternaria solani than the commercial fungicides carbendazim and chlorothalonil. Current research has laid a foundation for the application of nortopsentin analogues in plant protection.

Domino aryne precursor: Efficient construction of 2,4-disubstituted benzothiazoles

An aryne precursor with a potential to perform domino aryne chemistry was proposed and synthesized. The reaction of this reagent with benzothioamide derivatives could afford 2,4-disubstituted benzothiazole with sequential incorporation of C-S, C-N, and C-C bonds on the consecutive three positions of the aryne precursor.

Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARα agonists. 1. Discovery of a novel series of potent HDLc raising agents

The peroxisome proliferator activated receptors PPARα, PPARγ, and PPARδ are ligand-activated transcription factors that play a key role in lipid homeostasis. The fibrates raise circulating levels of high-density lipoprotein cholesterol and lower levels of triglycerides in part through their activity as PPARα agonists; however, the low potency and restricted selectivity of the fibrates may limit their efficacy, and it would be desirable to develop more potent and selective PPARα agonists. Modification of the selective PPARδ agonist 1 (GW501516) so as to incorporate the 2-aryl-2-methylpropionic acid group of the fibrates led to a marked shift in potency and selectivity toward PPARα agonism. Optimization of the series gave 25a, which shows EC50 = 4 nM on PPARα and at least 500-fold selectivity versus PPARγ and PPARγ. Compound 25a (GW590735) has been progressed to clinical trials for the treatment of diseases of lipid imbalance.