886499-03-2

Basic information

• Product Name: 2,6-DIFLUORO-4-METHOXYPHENYLACETONITRILE
• Synonyms: 2,6-DIFLUORO-4-METHOXYPHENYLACETONITRILE
• CAS NO: 886499-03-2
• Molecular Formula: C₉H₇F₂NO
• Molecular Weight: 183.15
• Mol File: 886499-03-2.mol

Chemical Properties

• Boiling Point: 232.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.237±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2,6-DIFLUORO-4-METHOXYPHENYLACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIFLUORO-4-METHOXYPHENYLACETONITRILE(886499-03-2)
• EPA Substance Registry System: 2,6-DIFLUORO-4-METHOXYPHENYLACETONITRILE(886499-03-2)

Safety Data

• Hazardous Substances Data: 886499-03-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Difluoro-4-methoxyphenylacetonitrile is used as a building block for the production of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the synthesis of active pharmaceutical ingredients, contributing to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 2,6-Difluoro-4-methoxyphenylacetonitrile is used as an intermediate in the manufacturing of agrochemicals. Its incorporation into these products can enhance their effectiveness in pest control and crop protection, leading to increased agricultural productivity.
Used in Organic Synthesis:
2,6-Difluoro-4-methoxyphenylacetonitrile is used as a key intermediate in the synthesis of complex organic molecules. Its unique chemical properties allow for the creation of a wide range of compounds with diverse applications in various industries.
Used in Research and Development:
Due to its unique chemical properties and reactivity, 2,6-Difluoro-4-methoxyphenylacetonitrile has potential applications in research and development. It can be used to explore new chemical reactions, develop novel synthetic methods, and investigate its potential uses in various fields.
It is important to handle 2,6-Difluoro-4-methoxyphenylacetonitrile with care and use appropriate safety precautions due to its potential hazards and reactivity.

Upstream product

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Downstream Products

• 1242020-16-1 2-(2,6-difluoro-4-methoxyphenyl)-3-oxobutanenitrile 
• 1242017-72-6 [4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazol-3-yl](2,4-difluorophenyl)methanol 
• 1242020-17-2 4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazol-3-yl amine 
• 1192117-58-0 3-chloro-5-(4-chlorophenyl)-4-(2,6-difluoro-4-methoxyphenyl)-1-methyl-1H-pyrazole 
• 1448006-03-8 5-(4-chlorophenyl)-4-(2,6-difluoro-4-methoxyphenyl)-1-methyl-1H-pyrazol-3-ylamine 
• 1448006-02-7 5-(4-chlorophenyl)-4-(2,6-difluoro-4-methoxyphenyl)-1-methyl-4,5-dihydro-1H-pyrazol-3-amine 
• 1242020-18-3 3-bromo-4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazole 
• 1242015-79-7 4-(2,6-difluoro-4-methoxyphenyl)-1,3-dimethyl-N-(2,4,6-trifluorophenyl)-1H-pyrazol-5 amine 

Relevant articles and documents

Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer

Tankyrases (TNKS/TNKS2) belong to the poly(ADP-ribose) polymerase family. Inhibition of their enzymatic activities attenuates the Wnt/β-catenin signaling, which plays an important role in cancer pathogenesis. We previously reported the discovery of RK-287107, a spiroindoline-based, highly selective, potent tankyrase inhibitor. Herein we describe the optimization process of RK-287107 leading to RK-582, which exhibits a markedly improved robust tumor growth inhibition in a COLO-320DM mouse xenograft model when orally administered. In addition to the dose-dependent elevation and attenuation of the levels of biomarkers AXIN2 and β-catenin, respectively, results of the TCF reporter and cell proliferation studies on COLO-320DM are discussed.

ANTICANCER AGENT

To provide an anticancer agent for preventing and/or treating cancer, comprising a tankyrase inhibitor containing a tankyrase inhibitory compound and a microtubule inhibitor containing a microtubule inhibitory compound as active ingredients.

PIPERIDINES OR PIPERIDONES SUBSTITUTED WITH UREA AND PHENYL

The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.

FUNGICIDAL PYRAZOLES AND THEIR MIXTURES

Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula (1), N-oxides, and salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as

FUNGICIDAL PYRAZOLES

Disclosed are compounds of Formula (1), including all geometric and stereoisomers, JV-oxides, and salts thereof, wherein Q1 is a phenyl ring, naphthalenyl ring system, a 5- to 6-membered fully unsaturated heterocyclic ring or an 8- to 10-membered heteroar