886500-75-0

Basic information

• Product Name: 2,3-DIFLUORO-4-METHOXYBENZYLAMINE
• Synonyms: 2,3-DIFLUORO-4-METHOXYBENZYLAMINE
• CAS NO: 886500-75-0
• Molecular Formula: C₈H₉F₂NO
• Molecular Weight: 173.16
• Mol File: 886500-75-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 32-35℃
• Boiling Point: 223.1 °C at 760 mmHg
• Flash Point: 88.7 °C
• Appearance: /
• Density: 1.22 g/cm³
• Vapor Pressure: 0.0982mmHg at 25°C
• Refractive Index: 1.495
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2,3-DIFLUORO-4-METHOXYBENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIFLUORO-4-METHOXYBENZYLAMINE(886500-75-0)
• EPA Substance Registry System: 2,3-DIFLUORO-4-METHOXYBENZYLAMINE(886500-75-0)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 886500-75-0(Hazardous Substances Data)

Usage

General Description

2,3-Difluoro-4-methoxybenzylamine is a chemical compound with the molecular formula C8H8F2NO. It is an amine derivative with the addition of a 2,3-difluoro-4-methoxybenzyl group, which consists of two fluorine atoms and one methoxy group attached to a benzene ring. 2,3-DIFLUORO-4-METHOXYBENZYLAMINE can be used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, and its properties make it a valuable building block in organic chemistry. It is important to handle 2,3-difluoro-4-methoxybenzylamine with caution, as it may have hazardous properties and should be stored and used according to safety guidelines.

InChI:InChI=1/C8H9F2NO/c1-12-6-3-2-5(4-11)7(9)8(6)10/h2-3H,4,11H2,1H3

Upstream product

• 256417-12-6 4-Methoxy-2,3-difluorobenzonitrile 

Downstream Products

• 1624256-35-4 8-(2,3-difluoro-4-methoxybenzyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrazino[2,1-f]purine-2,4(1H,3H)-dione 
• 1417878-93-3 (2,3-difluoro-4-methoxybenzyl)-[2-(5-methoxypyridin-3-yl)pyrimidin-4-yl]amine 
• 1417883-88-5 (2-chloropyrimidin-4-yl)-(2,3-difluoro-4-methoxybenzyl)amine 

Relevant articles and documents

Synthesis and Preliminary Evaluation of 11C-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4

Muscarinic acetylcholine receptors (mAChRs) have five distinct subunits (M1–M5) and are involved in the action of the neurotransmitter acetylcholine in the central and peripheral nervous system. Attributed to the promising clinical efficacy of xanomeline, an M1/M4-preferring agonist, in patients of schizophrenia and Alzheimer's disease, M1- or M4-selective mAChR modulators have been developed that target the topographically distinct allosteric sites. Herein we report the synthesis and preliminary evaluation of 11C-labeled positron emission tomography (PET) ligands based on a validated M4R positive allosteric modulator VU0467485 (AZ13713945) to facilitate drug discovery. [11C]VU0467485 and two other ligands were prepared in high radiochemical yields (>30 %, decay-corrected) with high radiochemical purity (>99 %) and high molar activity (>74 GBq μmol?1). In vitro autoradiography studies indicated that these three ligands possess moderate-to-high in vitro specific binding to M4R. Nevertheless, further physiochemical property optimization is necessary to overcome the challenges associated with limited brain permeability.