886501-07-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
2-(Benzylamino)-3-trifluoromethylpyridine is used as a building block for the synthesis of various pharmaceuticals and agrochemicals due to its unique structure and reactivity. Its presence in these compounds can enhance their efficacy and selectivity, making it a valuable component in drug discovery and development.
Used in Research and Development Laboratories:
2-(BENZYLAMINO)-3-TRIFLUOROMETHYLPYRIDINE is commonly used in research and development laboratories for its potential applications in drug discovery and medicinal chemistry. Its unique structural features and reactivity make it a promising candidate for the development of new therapeutic agents and agrochemical products.
Used as a Catalyst in Organic Reactions:
2-(Benzylamino)-3-trifluoromethylpyridine is also known for its potential use as a catalyst in various organic reactions. Its structural features allow it to facilitate and enhance the rates of chemical reactions, making it a valuable tool in the synthesis of complex organic molecules and the development of new synthetic methodologies.

Upstream product

• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 
• 100-46-9 benzylamine 

Downstream Products

• 1254205-45-2 4-(N-benzyl-N-(3-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoic acid 
• 1416556-04-1 N-benzhydryl-3-(trifluoromethyl)pyridin-2-amine 
• 1416556-11-0 3-phenyl-N-{phenyl[4-(trifluoromethyl)phenyl]methyl}-pyridin-2-amine 
• 1416556-09-6 N-{[4-chlorophenyl](phenyl)methyl}-3-phenylpyridin-2-amine 
• 1370412-48-8 N-((4-fluorophenyl)(phenyl)methyl)-3-phenylpyridin-2-amine 
• 1370412-47-7 N-((4-(tert-butyl)phenyl)(phenyl)methyl)-3-phenylpyridin-2-amine 
• 1370412-46-6 3-phenyl-N-(phenyl(p-tolyl)methyl)pyridin-2-amine 
• 1370412-45-5 N-benzhydryl-3-phenylpyridin-2-amine 
• 1416556-07-4 N-[(4-methoxyphenyl)(phenyl)methyl]-3-(trifluoromethyl)-pyridin-2-amine 
• 1416556-06-3 N-{[4-(tert-butyl)phenyl](phenyl)methyl}-3-(trifluoromethyl)-pyridin-2-amine 
• 1294517-65-9 N-benzyl-3-phenylpyridine-2-amine 

Relevant academic research and scientific papers

Mechanistic investigations and substrate scope evaluation of ruthenium-catalyzed direct sp3 arylation of benzylic positions directed by 3-substituted pyridines

A highly efficient direct arylation process of benzylic amines with arylboronates was developed that employs Ru catalysis. The arylation takes place with greatest efficiency at the benzylic sp3 carbon. If the distance to the activating aryl ring is increased, arylation is still possible but the yield drops significantly. Efficiency of the CH activation was found to be significantly increased by use of 3-substituted pyridines as directing groups, which can be removed after the transformation in high yield. Calculation of the energy profile of different rotamers of the substrate revealed that presence of a substituent in the 3-position favors a conformation with the CH2 group adopting a position in closer proximity to the directing group and facilitating C-H insertion. This operationally simple reaction can be carried out in argon atmosphere as well as in air and under neutral reaction conditions, displaying a remarkable functional group tolerance. Mechanistic studies were carried out and critically compared to mechanistic reports of related transformations.

SULFAMOYL BENZOIC ACID DERIVATIVES AS TRPM8 ANTAGONISTS

The present invention relates to sulfamoyl benzoic acid derivatives of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.