886508-73-2

Basic information

• Product Name: 3-amino-2-(p-tolyl)pyridine
• Synonyms: 3-amino-2-(p-tolyl)pyridine;2-(p-tolyl)pyridin-3-amine
• CAS NO: 886508-73-2
• Molecular Formula: C12H12N2
• Molecular Weight: 184
• Mol File: 886508-73-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-amino-2-(p-tolyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-2-(p-tolyl)pyridine(886508-73-2)
• EPA Substance Registry System: 3-amino-2-(p-tolyl)pyridine(886508-73-2)

Safety Data

• Hazardous Substances Data: 886508-73-2(Hazardous Substances Data)

Upstream product

• 6298-19-7 2-chloro-3-aminopyridine 
• 5720-05-8 4-methylphenylboronic acid 
• 195062-57-8 p-tolylboronic pinacol ester 

Relevant articles and documents

Asymmetric hydrogenation of 2-aryl-3-phthalimidopyridinium salts: Synthesis of piperidine derivatives with two contiguous stereocenters

Asymmetric hydrogenation of 2-aryl-3-phthalimido-pyridinium salts catalyzed by the Ir/SegPhos catalytic system was described, leading to the corresponding chiral piperidine derivatives bearing two contiguous chiral centers, with high levels of enantioselectivities and diastereoselectivities. A gram-scale experiment has demonstrated the utility of this approach. The phthaloyl group could be easily removed and then smoothly converted to key intermediate (+)-CP-99994 as one of the neurokinin 1 receptor antagonists.

Highly active and recyclable silica gel-supported palladium catalyst for mild cross-coupling reactions of unactivated heteroaryl chlorides

Silica gel-supported β-ketoiminatophosphane-Pd complex (Pd@SiO 2) was shown to be a highly active and long-lived catalyst for aqueous Suzuki, Stille and Sonogashira coupling reactions of heteroaryl chlorides. A wide range of heteroaryl chlorides could be efficiently coupled with different nucleophilic partners in the presence of only 0.5 mol% catalyst and under mild conditions. This is one of the most powerful heterogeneous catalysts for the couplings of diverse heteroaryl chlorides. Furthermore, the catalyst could be reused with almost consistent activity. The Royal Society of Chemistry 2010.

New catalysts for Suzuki-Miyaura coupling reactions of heteroatom- substituted heteroaryl chlorides

(Chemical Equation Presented) The new air-stable PdCl2{PR 2(Ph-R′)}2 complexes, readily prepared from commercial reagents, exhibit unique efficiency as catalysts for the Suzuki-Miyaura coupling reactions of a variety of he