88655-02-1

Usage

Uses

Used in Respiratory Applications:
2-(4-isopropoxyphenyl)ethanamine is used as a bronchodilator for the treatment of asthma and other respiratory conditions. It acts by stimulating the β2-adrenergic receptors, leading to the relaxation of smooth muscles in the airways, thereby improving airflow and reducing symptoms of respiratory distress.
Used in Cardiovascular Applications:
2-(4-isopropoxyphenyl)ethanamine is used as a vasodilator for the management of symptoms associated with bradycardia and heart block. By stimulating the β1-adrenergic receptors, it increases heart rate and cardiac output, making it a useful agent in emergency situations such as severe bradycardia or cardiac arrest.
Used in Emergency Medicine:
2-(4-isopropoxyphenyl)ethanamine is used as an emergency medication for the treatment of severe bradycardia or cardiac arrest. Its ability to increase heart rate and cardiac output makes it a critical component in the management of life-threatening cardiovascular events.

Upstream product

• 6946-32-3 1-isopropoxy-4-(2-nitrovinyl)benzene 

Downstream Products

• 88655-30-5 1-[2-(4-Isopropoxy-phenyl)-ethyl]-2-thioxo-tetrahydro-pyrimidin-4-one 
• 88655-20-3 1-[2-(4-Isopropoxy-phenyl)-ethyl]-dihydro-pyrimidine-2,4-dione 
• 663597-10-2 [2-(4-isopropoxy-phenyl)-ethyl]-(6-nitro-quinazolin-4-yl)-amine 
• 88655-10-1 3-[2-(4-Isopropoxy-phenyl)-ethylamino]-propionic acid methyl ester 

Relevant academic research and scientific papers

Diastereoselective synthesis of (±)-heliotropamide by a one-pot, four-component reaction

The first synthesis of heliotropamide is reported. The preparation of this 2-oxopyrrolidine (γ-lactam) natural product relied on a diastereoselective one-pot, four-component reaction (4CR) for the assembly of the core structure. On the basis of chemical shift correlation and NOESY experiments, the previously unknown alkene geometry of heliotropamide is assigned as E.

Total synthesis of (±)-armepavines and (±)-nuciferines from (2-nitroethenyl)benzene derivatives

A concise route to armepavine 1 and nuciferine 2 and 3, which can be isolated from the leaves of Nelumbo nucifera (Nymphaceae), has been achieved in which the longest linear sequence is only six steps from commercially available benzaldehyde in 28%, 21%, and 20% overall yield, respectively. The key transformations in the synthesis are the radical cyclization of aryl bromide with Bu3SnH and the Pictet-Spengler reaction of N-substituted amine with aldehyde. Copyright Taylor & Francis Group, LLC.

3-AMIDINOBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES IN THE PRODUCTION THEREOF

The present invention relates to 3-amidinobenzenesulfonamide derivatives represented by the general formula: wherein R1 represents a hydrogen atom or a hydroxy group; Y represents a single bond or an oxygen atom; and R2 represents a lower alkyl group or a group represented by the general formula: (wherein n represents 1 or 2; and T represents a hydrogen atom, a lower acyl group, a halo (lower acyl) group or a group represented by the general formula:-C(=NH)-W (wherein W represents a lower alkyl group)), and pharmaceutically acceptable salts thereof, which have an excellent activated blood coagulation factor X inhibitory activity and are useful as activated blood coagulation factor X inhibitors, and to pharmaceutical compositions comprising the same and intermediates thereof.