88656-06-8Relevant academic research and scientific papers
Conjugate Addition of Lithium Phenylthio- and Cyano-cuprate to Cyclic Enones. An Efficient Methylenecyclopentane Annulation Process
Piers, Edward,Karunaratne, Veranja
, p. 935 - 936 (1983)
Reaction of the cyclic enones (6)-(11) with the structurally interesting cuprate reagents (2) and (3) provides very good yields of the conjugate addition products (12)-(17); treatment of the latter substances with potassium hydride in tetrahydrofuran affords the methylenecyclopentane annulation products (18)-(23), respectively.
ORGANOTIN-BASED BIFUNCTIONAL REAGENTS: 4-CHLORO-2-LITHIO-1-BUTENE AND RELATED SUBSTANCES. METHYLENECYCLOPENTANE ANNULATIONS. TOTAL SYNTHESIS OF (+/-)-Δ9(12)-CAPNELLENE
Piers, Edward,Karunaratne, Veranja
, p. 1089 - 1104 (2007/10/02)
Transmetalation of 4-chloro-2-trimethylstannyl-1-butene (4) with MeLi in tetrahydrofuran (THF) at -78 deg C affords 4-chloro-2-lithio-1-butene (5).At low temperature (below approximately -50 to -60 deg C), 5 functions well as a bifunctional reagent.For ex
