886758-87-8Relevant academic research and scientific papers
THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C
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Page/Page column 191-192, (2013/06/06)
The present invention provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts h
Dipeptide nitrile inhibitors of cathepsin K
Altmann, Eva,Aichholz, Reiner,Betschart, Claudia,Buhl, Thomas,Green, Jonathan,Lattmann, Rene,Missbach, Martin
, p. 2549 - 2554 (2007/10/03)
A series of dipeptidyl nitriles as inhibitors of cathepsin K have been explored starting from lead structure 1 (Cbz-Leu-NH-CH2-CN, IC 50 = 39 nM). Attachment of non-natural amino acid side chains in P1 and modification of the P3 subu
